(1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline Chemical Properties

Melting point:

78-79℃

Density 

1.065

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Dichloromethane (Sparingly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Pale Beige

(1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline Usage And Synthesis

Uses

(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin (S676700), an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.

(1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline(180272-45-1)Related Product Information

• 3-QUINUCLIDINONE
• Solifenacin Related Compound 25
• Solifenacin Impurity 1
• 1-Phenyl-3,4-dihydroisoquinoline
• 1-Phenyl-1,2,3,4-tetrahydro-isoquinoline
• Ethyl (S)-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate
• Solifenacin succinate
• Solifenacin N-Oxide
• Solifenacin IMpurity
• (S)-(+)-3-Quinuclidinol
• 1-Azabicyclo[2.2.2]octan-3-ol, 3-acetate, (3R)-
• Solifenacin Related Compound 14
• Solifenacin Related Compound 13
• Dimethyl carbonate
• 4-(DICHLOROMETHYL)PYRIDINE HCL
• Solifenacin Related Compound 18
• Solifenacin Related Compound 29
• 3-Quinuclidinol