PI3-Kinase α Inhibitor 2 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMF:PBS(pH 7.2) (1:3): 0.25mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml

form 

White to off-white solid.

PI3-Kinase α Inhibitor 2 Usage And Synthesis

Description

PI3-Kinase α (PI3Kα) inhibitor 2 is an inhibitor of PI3K p110α (IC₅₀ = 2 nM in an enzyme assay). It is selective for p110α over p110β, p110γ, and PI3K C2β (IC₅₀s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR; IC₅₀ = 49 nM). PI3Kα inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC₅₀ value of 0.58 μM.

Definition

ChEBI: PI3-Kinase alpha Inhibitor 2 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and an organic heterobicyclic compound.

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