PI3-Kinase α Inhibitor 2
- Product Name
- PI3-Kinase α Inhibitor 2
- CAS No.
- 371943-05-4
- Chemical Name
- PI3-Kinase α Inhibitor 2
- Synonyms
- PI3K-IN-18;Compound 15e;PI3-Kinase α Inhibitor 2;Compound 15e, 98.0+ % (HPLC);PI3-Kinase .alpha. Inhibitor 2;PI 3-Kinase Inhibitor 2 B-0304;PI3-Kinase α Inhibitor 2 Exclusive;3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol;3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]Phenol;Phenol, 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-
- CBNumber
- CB32592007
- Molecular Formula
- C16H15N3O2S
- Formula Weight
- 313.37
- MOL File
- 371943-05-4.mol
PI3-Kinase α Inhibitor 2 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMF:PBS(pH 7.2) (1:3): 0.25mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
- form
- White to off-white solid.
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 10010177
- Product name
- PI3-Kinase α Inhibitor 2
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $28
- Updated
- 2024/03/01
- Product number
- 10010177
- Product name
- PI3-Kinase α Inhibitor 2
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 10010177
- Product name
- PI3-Kinase α Inhibitor 2
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $207
- Updated
- 2024/03/01
- Product number
- 10010177
- Product name
- PI3-Kinase α Inhibitor 2
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $357
- Updated
- 2024/03/01
- Product number
- 1688AH
- Product name
- Compound15E
- Packaging
- 5mg
- Price
- $326
- Updated
- 2021/12/16
PI3-Kinase α Inhibitor 2 Chemical Properties,Usage,Production
Description
PI3-Kinase α (PI3Kα) inhibitor 2 is an inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay). It is selective for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR; IC50 = 49 nM). PI3Kα inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC50 value of 0.58 μM.
Uses
PI3K-IN-18 (Compound 1) is a PI3K inhibitor, and can also effectively inhibit the homologous enzymemTOR. The IC50 values of PI3K-IN-18 for mTOR and PI3K-α were 49 nM and 41 nM, respectively[1].
Definition
ChEBI: PI3-Kinase alpha Inhibitor 2 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and an organic heterobicyclic compound.
IC 50
mTOR: 49 nM (IC50); PI3Kα: 41 nM (IC50)
References
[1] Verheijen, Jeroen C et al. “Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K.” Bioorganic & medicinal chemistry letters vol. 20,1 (2010): 375-9. DOI:10.1016/j.bmcl.2009.10.075
PI3-Kinase α Inhibitor 2 Preparation Products And Raw materials
Raw materials
Preparation Products
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