Diphosphoryl chloride Chemical Properties

Melting point:

<-50°C

Boiling point:

90 °C12 mm Hg(lit.)

Density 

1.82 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.476

Flash point:

101°C/10mm

storage temp. 

−20°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Liquid

color 

Colorless to pale yellow

Specific Gravity

1.82

Water Solubility 

Reacts violently with waterMiscible with most organic solvents.

Sensitive 

Air & Moisture Sensitive

InChIKey

CNTIXUGILVWVHR-UHFFFAOYSA-N

CAS DataBase Reference

13498-14-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

14-34

Safety Statements 

26-36/37/39-45-60-30-23-20-8

RIDADR 

UN 3264 8/PG 2

WGK Germany 

3

F 

10-21

HazardClass 

8

PackingGroup 

II

HS Code 

28121049

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Diphosphoryl chloride Usage And Synthesis

Chemical Properties

Diphosphoryl chloride is a colorless liquid that produces smoke upon exposure to air and reacts violently with water. At temperatures as low as -30°C, it can react with water to form dichlorophosphoric acid (HPO2C12). The compound is soluble in a variety of solvents, including phosphorus trichloride, phosphorus oxychloride, thionyl chloride, benzene, other hydrocarbons, ether, and nitrobenzene.

Uses

Pyrophosphoryl chloride serves as a reductive chlorination reagent used in the synthesis of quetiapine. It acts as a phosphorylating agent involved in nucleoside synthesis. It plays an important role in Vilsmeier formylation and glyoxylation reactions.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand

Diphosphoryl chloride(13498-14-1)Related Product Information

• Boron oxide
• Pivaloyl chloride
• Chloroacetyl chloride
• Choline chloride
• Calcium chloride
• Oxalyl chloride
• Acryloyl chloride
• Sulfuryl chloride
• Ammonium chloride
• Yttrium oxide
• Bismuth trioxide
• Tosyl chloride
• Dititanium trioxide
• Thionyl chloride
• COBALT(III) OXIDE BLACK
• Benzoyl chloride
• Phosphorus trioxide
• Phosphorus oxychloride