(R)-2-(methoxycarbonylamino)-2-phenylacetic acid Chemical Properties

Melting point:

120 °C

Boiling point:

391.3±35.0 °C(Predicted)

Density 

1.283±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

3.96±0.10(Predicted)

color 

White to Almost white

optical activity

Consistent with structure

(R)-2-(methoxycarbonylamino)-2-phenylacetic acid Usage And Synthesis

Uses

(R)-2-((Methoxycarbonyl)amino)-2-phenylacetic acid is a Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) derivative[1].

Synthesis

D-Phenylglycine (10.0 g, 66.1 mmol) and sodium hydroxide (21.2 g, 265 mmol) were dissolved in water (60 mL) at 0°C and stirred until completely dissolved. Subsequently, methyl chloroformate (10.2 mL, 133 mmol) was added slowly and dropwise over 20 minutes. The reaction mixture was continued to be stirred at 0°C for 1 hour. Upon completion of the reaction, it was acidified with concentrated hydrochloric acid (25 mL, 300 mmol) to pH < 2. The acidic aqueous phase was extracted with ethyl acetate (3 x 100 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. After filtration to remove the desiccant, the organic phase was concentrated under reduced pressure to afford N-methoxycarbonyl-D-phenylglycine (Int-2a, 12.6 g, 91% yield), which could be used for subsequent reactions without further purification.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

(R)-2-(methoxycarbonylamino)-2-phenylacetic acid(50890-96-5)Related Product Information

• PHENACETURIC ACID
• Moc-Ile-OH
• Moc-Val-Val-OH
• 1,2-Pyrrolidinedicarboxylicacid,1-methylester,(2S)-(9CI)
• (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid
• N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER
• Velpatasvir intermediate
• Velpatasvir
• Velpatasvir intermediate
• Velpatasvir intermediate
• Velpatasvir Co Povidone
• Velpatasvir intermediate
• (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
• BOC-L-PYROGLUTAMIC ACID BENZYL ESTER
• Velpatasvir-A12
• MOC-D-Valine
• Methoxycarbonyl-L-tert-leucine
• Benzeneacetic acid, a-[(Methoxycarbonyl)aMino]-, (S)-