Velpatasvir Chemical Properties

Melting point:

>170oC (dec.)

Density 

1.314±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO (>25 mg/ml)

form 

solid

pka

10.75±0.46(Predicted)

color 

Pale yellow

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Velpatasvir Usage And Synthesis

Description

Velpatasvir (1377049-84-7) is an extremely potent pan-genotypic hepatitis C virus (HCV) NS5A inhibitor.1 It is a component of Epclusa? and Vosevi?, two clinically useful medications with 98% and 97%, respectively, cure rates for HCV.? It displayed EC50’s for GTs 1-4, 6a ranging from 6-16 pM, GT5a at 75 pM, and GT6e at 130 pM. Velpatasvir also displayed an excellent barrier to viral resistance. It has been shown in silico, that velpatasvir binds to the SARS-CoV-2 spike protein and may be a potential therapeutic.2

Uses

Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.

Definition

ChEBI: Velpatasvir is a complex organic heteropentacyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with sofosbuvir (under the brand name Epclusa) for treatment of patients with chronic hepatitis C of all six major genotypes. It has a role as an antiviral drug and a hepatitis C virus nonstructural protein 5A inhibitor. It is an organic heteropentacyclic compound, a N-acylpyrrolidine, a L-valine derivative, a carbamate ester, a member of imidazoles, a ring assembly and an ether.

brand name

Epclusa, Sofosvel, Velpanat (all in combination with sofosbuvir)

References

Link et al. (2019), Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi? and Epclusa?; Bioorg. Med. Chem. Lett., 29 2415 Kadioglu et al. (2020), Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning; Comput. Biol. Med. 133 104359

Velpatasvir(1377049-84-7)Related Product Information

• (S)-1-tert-Butyl 5-methyl 2-((tert-butoxycarbonyl)amino)pentanedioate
• ZANAMIVIR HYDRATE
• Dutasteride
• Tacrolimus
• Zofenopril calcium
• Sofosbuvir
• Rituximab
• Levofloxacin hydrochloride
• (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid
• N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER
• Velpatasvir intermediate
• Velpatasvir intermediate
• Velpatasvir intermediate
• (R)-2-(methoxycarbonylamino)-2-phenylacetic acid
• Velpatasvir Co Povidone
• Velpatasvir intermediate
• (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
• BOC-L-PYROGLUTAMIC ACID BENZYL ESTER