Basic information Safety Supplier Related

GSK2110183

Basic information Safety Supplier Related

GSK2110183 Basic information

Product Name:
GSK2110183
Synonyms:
  • N-[(1S)-2-Amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide
  • GSK2110183
  • Afuresertib (GSK2110183)
  • CS-1729
  • N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide
  • GSK2110183;GSK 2110183;GSK-2110183
  • 2-Thiophenecarboxamide, N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-
  • Afuresertib-F free base
CAS:
1047634-63-8
MF:
C18H16Cl2F2N4OS
MW:
445.31
Mol File:
1047634-63-8.mol
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GSK2110183 Chemical Properties

Boiling point:
539.7±50.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
12.92±0.46(Predicted)
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GSK2110183 Usage And Synthesis

Description

Afuresertib-F is an analogue of Afuresertib with one more flurorine-atom compared to its parent drug Afuresertib. Afuresertib-F is an ATK inhibitor. Afuresertib, also known as GSK-2110183 or GSK-2110183C, is an cancer drug candidate under clinical trial.

Uses

An ATK inhibitorAfuresertib-F is used in methods of treating myeloproliferative neoplasms using a combination of a MDM2 inhibitor and a therapeutic agent.

GSK2110183Supplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Email
3003855609@qq.com
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Email
sales@letopharm.com
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com