GSK2110183
GSK2110183 Basic information
- Product Name:
- GSK2110183
- Synonyms:
-
- N-[(1S)-2-Amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide
- GSK2110183
- Afuresertib (GSK2110183)
- CS-1729
- N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide
- GSK2110183;GSK 2110183;GSK-2110183
- 2-Thiophenecarboxamide, N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-
- Afuresertib-F free base
- CAS:
- 1047634-63-8
- MF:
- C18H16Cl2F2N4OS
- MW:
- 445.31
- Mol File:
- 1047634-63-8.mol
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GSK2110183 Chemical Properties
- Boiling point:
- 539.7±50.0 °C(Predicted)
- Density
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 12.92±0.46(Predicted)
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GSK2110183 Usage And Synthesis
Description
Afuresertib-F is an analogue of Afuresertib with one more flurorine-atom compared to its parent drug Afuresertib. Afuresertib-F is an ATK inhibitor. Afuresertib, also known as GSK-2110183 or GSK-2110183C, is an cancer drug candidate under clinical trial.
Uses
An ATK inhibitorAfuresertib-F is used in methods of treating myeloproliferative neoplasms using a combination of a MDM2 inhibitor and a therapeutic agent.
GSK2110183Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
LETOPHARM LIMITED
- Tel
- +86-21-5821 5861
- sales@letopharm.com
Shanghai YuanQi Biotechnology Co., Ltd.
- Tel
- +86-2332782371 +86-18120098618
- sales@adobechem.com
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