Ripasudil Hydrochloride Chemical Properties

Melting point:

258-259 °C (decomp)

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Sparingly)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

Ripasudil Hydrochloride Usage And Synthesis

Uses

Ripasudil (Glanatec TM, Kowa Pharmaceutical), a close derivative of fasudil, is another Rho kinase inhibitor approved in Japan at the end of 2014 for the treatment of glaucoma and ocular hypertensionwhen other therapeutic agents are not effective or cannot be administered. Additionally, ripasudil has been tested in diabetic retinopathy clinical trials and shown to promote corneal endothelial cell proliferation, endothelium regeneration, and wound healing.

Uses

Ripasudil Hydrochloride Dihydrate is a derivative of fasudil and a rho kinase inhibitor (1,2). It is used for the treatment of glaucoma and ocular hypertension.

Ripasudil Hydrochloride(223644-02-8)Related Product Information

• Ripasudil
• Ripasudil hydrochloride dihydrate