Ripasudil Chemical Properties

Boiling point:

497.2±55.0 °C(Predicted)

Density 

1.293±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Soluble in DMSO

pka

9.70±0.40(Predicted)

Ripasudil Usage And Synthesis

Description

Ripasudil (Glanatec TM, Kowa Pharmaceutical), a close derivative of fasudil, is another Rho kinase inhibitor approved in Japan at the end of 2014 for the treatment of glaucoma and ocular hypertensionwhen other therapeutic agents are not effective or cannot be administered. Additionally, ripasudil has been tested in diabetic retinopathy clinical trials and shown to promote corneal endothelial cell proliferation, endothelium regeneration, and wound healing.

Definition

ChEBI: Ripasudil is a member of isoquinolines.

Ripasudil(223645-67-8)Related Product Information

• Ripasudil hydrochloride dihydrate
• Ripasudil Hydrochloride
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