4-AMINOBENZAMIDINE HYDROCHLORIDE
4-AMINOBENZAMIDINE HYDROCHLORIDE Basic information
- Product Name:
- 4-AMINOBENZAMIDINE HYDROCHLORIDE
- Synonyms:
-
- 4-aminobenzenecarboximidamidemonohydrochloride
- 4-amino-benzenecarboximidamidmonohydrochloride
- p-aminobenzamidinehydrochloride
- p-amino-benzamidinmonohydrochloride
- TIMTEC-BB SBB003838
- P-AMINOBENZAMIDINE HCL
- 4-AMINOBENZAMIDINE HYDROCHLORIDE
- 4-Aminobenzamidine monohydrochloride
- CAS:
- 7761-72-0
- MF:
- C7H10ClN3
- MW:
- 171.63
- Mol File:
- 7761-72-0.mol
4-AMINOBENZAMIDINE HYDROCHLORIDE Chemical Properties
- storage temp.
- Sealed in dry,Room Temperature
4-AMINOBENZAMIDINE HYDROCHLORIDE Usage And Synthesis
Uses
4-Aminobenzimidamide Hydrochloride (Compound 4a) is a MRGPRX1 agonist. 4-Aminobenzimidamide Hydrochloride can be used in the study of MRGPRX1-mediated analgesic effects[1].
Synthesis
4-aminophenyl ethyl imino ether hydrochloride(3.0 g) was added to a solution of ammonia (12g) in ethanol(150ml, ~8% mass percent) with stirring at room temperature for 24 hours. The reaction mixture was filtered and concentrated in vacuo, and acidated with hydrochloric acid (5ml, 63%). Absorbent charcoal was used to purify. The mixture was filtered, and concentrated and dried in vacuo at room temperature to give 5.0 g(86%) of 4-aminobenzamidine hydrochloride was obtained as a bright yellow solid.
References
[1] Prchalová E, et al. Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. J Med Chem. 2019 Sep 26;62(18):8631-8641. DOI:10.1021/acs.jmedchem.9b01003
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