1-Boc-4-(4-fluoro-phenylamino)-piperidine Chemical Properties

Boiling point:

400.4±40.0 °C(Predicted)

Density 

1.159±0.06 g/cm3(Predicted)

pka

5.09±0.20(Predicted)

InChI

InChI=1S/C16H23FN2O2/c1-16(2,3)21-15(20)19-10-8-14(9-11-19)18-13-6-4-12(17)5-7-13/h4-7,14,18H,8-11H2,1-3H3

InChIKey

TUYSUNKDSSHKHM-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCC(NC2=CC=C(F)C=C2)CC1

1-Boc-4-(4-fluoro-phenylamino)-piperidine Usage And Synthesis

Chemical Properties

1-Boc-4-(4-Fluoro-Phenylamino)-Piperidine (Tert-Butyl 4- (4-fluoroanilino) Piperidine-1-Carboxylate) is a white solid.

Uses

1-Boc-4-(4-fluoro-phenylamino)-piperidine (Tert-Butyl 4- (4-fluoroanilino) Piperidine-1-Carboxylate) is a heterocyclic derivative and can be used as a pharmaceutical intermediate.

Preparation

Sodium cyanoborohydride (661 mg, 10.0 mmol) was added to a methylene chloride solution (30 ml) of t-butyl 4-oxopiperidine-1-carboxylate (2.66 g, 13.1 mmol), 4-fluoroaniline (1.46 g, 13.1 mmol) and acetic acid (0.750 ml, 13.1 mmol), at 0°C, and stirring was carried out at room temperature for 15 hours. A saturated aqueous sodium hydrogencarbonate solution was added to the reaction solution, followed by extraction with ethyl acetate, and the extract was washed sequentially with water and saline, and dried over anhydrous sodium sulfate. The organic layer was concentrated and the resulting residue was washed with diisopropyl ether, followed by drying to afford 1-Boc-4-(4-Fluoro-Phenylamino)-Piperidine. Yield 80%.

1-Boc-4-(4-fluoro-phenylamino)-piperidine(288573-56-8)Related Product Information

• tert-butyl 3-oxo-2,3-dihydro-1H-pyrazole-1-carboxylate
• tert-butyl 2-amino-1H-benzo[d]imidazole-1-carboxylate
• 1-N-Boc-4-(Phenylamino)piperidine
• 1-Boc-4-(4-fluoro-phenylamino)-piperidine