H-D-GLU(TRP-OH)-OH Chemical Properties

Boiling point:

737.3±60.0 °C(Predicted)

Density 

1.428

storage temp. 

−20°C

pka

2.22±0.10(Predicted)

Sequence

H-γ-Glu-Trp-OH

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

H-D-GLU(TRP-OH)-OH Usage And Synthesis

Uses

Bestim is a dipeptide, which exhibits high affinity to murine peritoneal macrophages, thymocytes, and plasma membranes isolated from these cells, with Kds of 3.1, 2.1, 18.6 and 16.7 nM, respectively. Bestim inhibits adenylate cyclase in the membranes of murine macrophages and thymocytes. Bestim exhibits immunomodulatory efficacy[1].

Definition

ChEBI: A glutamyl-L-amino acid obtained by formal condensation of the gamma-carboxy group of glutamic acid with the amino group of tryptophan.

References

[1] Kolobov AA, et al., Interaction of the synthetic immunomodulatory dipeptide bestim with murine macrophages and thymocytes. Bioorg Khim. 2008 Jan-Feb;34(1):43-9. Russian. DOI:10.1134/s1068162008010044

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