Basic information Safety Supplier Related

8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT

Basic information Safety Supplier Related

8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT Basic information

Product Name:
8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT
Synonyms:
  • 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT
  • ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, 8-CHLORO-, SP-ISOMER, SODIUM SALT
  • SP-8-CL-CAMPS, NA
  • SP-8-CL-CAMPS SODIUM SALT
  • 8-chloroadenosine-3’,5’-cyclicmonophosphorothioate
  • 8-chloroadenosine-3’,5’-cyclicmonophosphorothioate,sp-isomer(sp-8-cl-camps)
  • 8-Chloroadenosine-3'',5''-cyclic monophosphothioate sodium salt Sp isomer
  • Sp-8-Cl-cAMPS
CAS:
142754-28-7
MF:
C10H10ClN5NaO5PS
MW:
401.7
Mol File:
142754-28-7.mol
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8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT Usage And Synthesis

Uses

Sp-8-Cl-cAMPS is an analog of cAMP (HY-B1511) and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC50 of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with Ka of 0.25 and 3.2 μM[1].

References

[1] Yokozaki H, et al., Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res. 1992 May 1;52(9):2504-8. PMID:1314695

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