DNP-PEG4-NHS ester
DNP-PEG4-NHS ester Basic information
- Product Name:
- DNP-PEG4-NHS ester
- Synonyms:
-
- (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
- DNP-NH-PEG(4)-NHS
- DNP-PEG4-NHS ester
- DNP-PEG4-NHS
- 1-(2,4-Dinitrophenylamino)-3,6,9,12-tetraoxapentadecanoic acid succinimidyl ester
- 2,5-Pyrrolidinedione, 1-[3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-oxopropoxy]- (9CI)
- DNP-dPEG??-NHS ester
- 2,5-Pyrrolidinedione,1-[3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-oxopropoxy]-
- CAS:
- 858126-78-0
- MF:
- C21H28N4O12
- MW:
- 528.47
- Mol File:
- 858126-78-0.mol
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DNP-PEG4-NHS ester Chemical Properties
- storage temp.
- Storage temp. -20°C
- form
- Viscous Liquid
- color
- Light yellow to green yellow
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DNP-PEG4-NHS ester Usage And Synthesis
Description
DNP-PEG4-NHS ester is a PEG linker containing a DNP moiety and NHS ester terminal group. DNP is involved in biological applications such as participating in ion transport across membranes. The NHS ester can react with primary amines to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.
Uses
DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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