MONO-METHYL POLYETHYLENE GLYCOL 5'000ACETIC ACID N-SUCCINIMIDYL ESTER Chemical Properties

storage temp. 

−20°C

form 

Solid

color 

White to off-white

α-end

methoxy

Ω-end

NHS ester

InChI

InChI=1S/C8H11NO6.C3H8O2/c10-3-4-14-5-8(13)15-9-6(11)1-2-7(9)12;1-5-3-2-4/h10H,1-5H2;4H,2-3H2,1H3

InChIKey

NYXRHTOXAYVBMV-UHFFFAOYSA-N

SMILES

O(C(C([H])([H])OC([H])([H])C([H])([H])O[H])=O)N1C(C([H])([H])C([H])([H])C1=O)=O.O(C([H])([H])[H])C([H])([H])C([H])([H])O[H]

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

3-10-23

MSDS

• Language:English Provider:SigmaAldrich

MONO-METHYL POLYETHYLENE GLYCOL 5'000ACETIC ACID N-SUCCINIMIDYL ESTER Usage And Synthesis

Uses

m-PEG-NHS ester (MW 2000) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.

References

[1] Jin M, et al. Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo[J]. Acta Pharmaceutica Sinica B, 2013, 3(2): 123-129.

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