GNE-140 (racemate)
GNE-140 (racemate) Basic information
- Product Name:
- GNE-140 (racemate)
- Synonyms:
-
- GNE-140 racemate (GNE 140 racemate
- GNE-140 (racemate)
- 3-((2-chlorophenyl)thio)-6-(4-morpholinophenyl)-6-(thiophen-3-yl)piperidine-2,4-dione
- 2,4-Piperidinedione, 3-[(2-chlorophenyl)thio]-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-
- CAS:
- 1802977-61-2
- MF:
- C25H23ClN2O3S2
- MW:
- 499.04
- Mol File:
- 1802977-61-2.mol
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GNE-140 (racemate) Chemical Properties
- Boiling point:
- 739.0±60.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : ≥ 34 mg/mL (68.13 mM)
- pka
- 9.61±0.70(Predicted)
- form
- Solid
- color
- White to off-white
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GNE-140 (racemate) Usage And Synthesis
Description
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor
in vitro
Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion.
GNE-140 (racemate)Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Wuxi AppTec
- Tel
- 022-59987777 13552403979
- jia_guoqiang@wuxiapptec.com
Shanghai Gugang New Materials Technology Co. Ltd.
- Tel
- 021-51317962
- 296935822@qq.com