4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Chemical Properties

Melting point:

-30℃

Boiling point:

51-53 °C/12 mmHg (lit.)

Density 

1.18 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.406(lit.)

Flash point:

125 °F

storage temp. 

2-8°C

solubility 

soluble in Chloroform, Methanol

form 

Liquid

color 

Colorless to yellow

Sensitive 

Moisture Sensitive

InChIKey

YKYIFUROKBDHCY-ONEGZZNKSA-N

LogP

1.414 (est)

CAS DataBase Reference

17129-06-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,F

Risk Statements 

10-40

Safety Statements 

16-36-36/37

RIDADR 

UN 1224 3/PG 3

WGK Germany 

3

Hazard Note 

Flammable/Harmful

HazardClass 

3

PackingGroup 

III

HS Code 

29147000

MSDS

• Language:English Provider:SigmaAldrich

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Usage And Synthesis

Chemical Properties

light yellow liquid

Uses

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one may be used in the synthesis of 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones. It may be used for the synthesis of β-alkyl- or dialkylamino substituted enones bearing a CF₃ group.

General Description

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one reacts with phenylmagnesium bromide to afford ethoxy group substitution products, while it reacts with organozinc compounds to yield products arising from 1,2-addition to the carbonyl group. 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one on heating with triethyl phosphite affords [4+2] cycloaddition product, 2,2,2-triethoxy 2,3-dihydro-3-ethoxy-5-trifluoromethyl-1,2λ⁵-oxaphospholene, which on hydrolysis affords a 2-oxo-2-hydroxy-2, 3-dihydro-3-hydroxy 5-trifluoromethyl-1,2λ⁵-oxaphospholen. It reacts with amino to give the N-protected amino acids, which is useful for the peptide synthesis.

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one(17129-06-5)Related Product Information

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• DIETHOXYMETHANE
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• Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
• 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
• Ethoxy
• TRIFLUOROACETYLKETENEDIETHYLACETAL
• 3-BROMO-4-ETHOXY-1,1,1-TRIFLUORO-BUT-3-EN-2-ONE
• 3-CHLORO-4-ETHOXY-1,1,1-TRIFLUORO-BUT-3-EN-2-ONE
• (E)-4-AMINO-4-ETHOXY-1,1,1-TRIFLUOROBUT-3-EN-2-ONE
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• RARECHEM AL FK 0077
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• 3-[3,3,3-TRIFLUORO-2-OXOPROP-(Z)-YLIDENE]-3H-ISOBENZOFURAN-1-ONE