4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
- Product Name
- 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
- CAS No.
- 17129-06-5
- Chemical Name
- 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
- Synonyms
- (E)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one;AKOS B022234;uoro-3-buten-2-one;ART-CHEM-BB B022234;4-Ethoxy-1,1,1-trifL;2-ethoxyvinyltrifluoroMethylketone;4-ethoxy-1,1,1-trifluoro-3-buten-2-on;4-Ethoxy-1,1,1-trifluorobut-3-en-2-on;4-Ehoxy-1,1,1-trifluoro-3-buten-2-one;4-Ethoxy-1,1,1-trifluoro-3-butan-2-one
- CBNumber
- CB3315617
- Molecular Formula
- C6H7F3O2
- Formula Weight
- 168.11
- MOL File
- 17129-06-5.mol
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Property
- Melting point:
- -30℃
- Boiling point:
- 51-53 °C/12 mmHg (lit.)
- Density
- 1.18 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.406(lit.)
- Flash point:
- 125 °F
- storage temp.
- 2-8°C
- solubility
- soluble in Chloroform, Methanol
- form
- Liquid
- color
- Colorless to yellow
- Sensitive
- Moisture Sensitive
- InChI
- InChI=1S/C6H7F3O2/c1-2-11-4-3-5(10)6(7,8)9/h3-4H,2H2,1H3
- InChIKey
- YKYIFUROKBDHCY-ONEGZZNKSA-N
- SMILES
- C(F)(F)(F)C(=O)C=COCC
- LogP
- 1.414 (est)
- CAS DataBase Reference
- 17129-06-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,F
- Risk Statements
- 10-40
- Safety Statements
- 16-36-36/37
- RIDADR
- UN 1224 3/PG 3
- WGK Germany
- 3
- Hazard Note
- Flammable/Harmful
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29147000
- Storage Class
- 3 - Flammable liquids
- Hazard Classifications
- Aquatic Chronic 3
Carc. 2
Flam. Liq. 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H351Suspected of causing cancer
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P273Avoid release to the environment.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 407771
- Product name
- 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
- Purity
- contains 0.5% BHT as stabilizer, technical grade
- Packaging
- 5g
- Price
- $90.2
- Updated
- 2024/03/01
- Product number
- JK380337
- Product name
- 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- 057760
- Product name
- (E)-4-Ethoxy-1,1,1-trifluorobut-3-en-2-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 2317-3-41
- Product name
- 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 2317-3-41
- Product name
- 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one
- Purity
- 95%
- Packaging
- 5G
- Price
- $40
- Updated
- 2021/12/16
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Chemical Properties,Usage,Production
Chemical Properties
light yellow liquid
Uses
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one may be used in the synthesis of 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones. It may be used for the synthesis of β-alkyl- or dialkylamino substituted enones bearing a CF3 group.
General Description
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one reacts with phenylmagnesium bromide to afford ethoxy group substitution products, while it reacts with organozinc compounds to yield products arising from 1,2-addition to the carbonyl group. 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one on heating with triethyl phosphite affords [4+2] cycloaddition product, 2,2,2-triethoxy 2,3-dihydro-3-ethoxy-5-trifluoromethyl-1,2λ5-oxaphospholene, which on hydrolysis affords a 2-oxo-2-hydroxy-2, 3-dihydro-3-hydroxy 5-trifluoromethyl-1,2λ5-oxaphospholen. It reacts with amino to give the N-protected amino acids, which is useful for the peptide synthesis.
Synthesis
354-34-7
109-92-2
59938-06-6
Example 1 Preparation of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one Ethyl vinyl ether (60 g) and triethylamine (28 g) were placed in an autoclave. The reaction vessel was cooled to 10°C to 15°C with continuous stirring. Trifluoroacetyl fluoride (99 g) was added in batches through an impregnation line of stainless steel cylinders at a temperature of 30°C to 40°C and a pressure of 5 to 10 kg/cm2 . After the addition was completed, the reaction mixture was continued to be stirred for 30 min until the reactor pressure was reduced to 0.25 to 0.5 kg/cm2. Excess trifluoroacetyl fluoride was removed by distillation under reduced pressure, followed by washing the reaction mixture with water. The organic layer was separated and concentrated by decompression to give the title product 4-ethoxy-1,1,1-trifluoro-3-buten-2-one. Yield: 86.2%; purity: 98.2%.
References
[1] Patent: WO2015/11728, 2015, A1. Location in patent: Page/Page column 7
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one Suppliers
- Tel
- 0519-85607885 13776800733
- Fax
- +86 519 8552788
- email@standardschem.com
- Country
- China
- ProdList
- 114
- Advantage
- 62
- Tel
- 021-021-50400622 15618790390
- info@chemart.cn
- Country
- China
- ProdList
- 238
- Advantage
- 58
- Tel
- 519-519-88783621 13906127738
- Fax
- +86-519-88495082
- xjq@xialichem.com
- Country
- China
- ProdList
- 170
- Advantage
- 70
- Tel
- 18171205315; 18171205315
- 1213219329@qq.com
- Country
- China
- ProdList
- 999
- Advantage
- 58
- Tel
- 15853386234
- 1269994174@qq.com
- Country
- China
- ProdList
- 29
- Advantage
- 58
- Tel
- 021-65170832 15601903708
- qinba_1@163.com
- Country
- China
- ProdList
- 406
- Advantage
- 60
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
View Lastest Price from 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one manufacturers
- Product
- 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 17129-06-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2025-04-01
- Product
- 4-Ethoxy-1,1,1-trifluorobut-3-en-2-one 17129-06-5
- Price
- US $750.00/Kg
- Min. Order
- 0.100Kg
- Purity
- 98
- Supply Ability
- 5000 Kg
- Release date
- 2025-03-29
- Product
- 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 17129-06-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-22