4-Fluoroacetophenone Chemical Properties

Melting point:

4 °C

Boiling point:

77-78 °C10 mm Hg(lit.)

Density 

1.143 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.511(lit.)

Flash point:

160 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Ethyl Acetate

form 

Liquid

Specific Gravity

1.138

color 

Clear colorless to slightly yellow

BRN 

386013

InChIKey

ZDPAWHACYDRYIW-UHFFFAOYSA-N

CAS DataBase Reference

403-42-9(CAS DataBase Reference)

NIST Chemistry Reference

Ethanone, 1-(4-fluorophenyl)-(403-42-9)

EPA Substance Registry System

4'-Fluoroacetophenone (403-42-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-23

WGK Germany 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29147090

MSDS

• Language:English Provider:1-(4-Fluorophenyl)ethanone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Fluoroacetophenone Usage And Synthesis

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

4-Fluoroacetophenone can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Uses

4’-Fluoroacetophenone is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products.

Uses

4’Fluoroacetophenone is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products.

Synthesis

General procedure: Oximes (1.0 mmol), Amberlyst-15 (0.02 g), FPA53-NO2(0.02 g), and solvent (1.5 mL) were introduced into a 25-cm-high, 90-mL autoclave with a glass tube inside equipped with magnetic stirrer (Scheme 2). Then the autoclave was charged with oxygen to 0.1 MPa. The reaction mixture was stirred at desirable temperature for special time. Progress of the reaction was monitored by thin-layer chromatography (TLC) or gas chromatography (GC). After the reaction, the resin (Amberlyst-15 and FPA53-NO2) was separated from the reaction mixture by filtration and extracted with 3 mL CH3CN (2 1.5 ml). The solvent was removed under reduced pressure. The residue was further purified by column chromatography on silica gel (300 mesh) with hexane/ethyl acetate to give the corresponding carbonyl compounds.

4-Fluoroacetophenone(403-42-9)Related Product Information

• 4'-Methylacetophenone
• 4-Nitroacetophenone
• 4'-(Trifluoromethyl)acetophenone
• L-PICEIN
• 2-Bromoacetophenone
• Acetophenone
• 3-Nitroacetophenone
• 4'-Hydroxyacetophenone
• 4'-Fluoropropiophenone
• 1-(4-FLUORO-PHENYL)-BUTAN-1-ONE
• 4-Dechloro-4-(4-chlorophenyl) Haloperidol Decanoate
• Haloperidol Lauroate
• 4-Defluoro-2-fluoro Haloperidol Decanoate
• 4-[4-(4-Chlorophenyl)-4-hydroxypiperidine]-4-defluorohaloperidol Decanoate
• Haloperidol Octanoate
• 4-Dechloro-4-(3-chlorophenyl) Haloperidol Decanoate
• ODANWSUZWFYXTO-UHFFFAOYSA-N
• 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidyl decanoate