Bis(cyclohexanone)oxaldihydrazone Chemical Properties

Melting point:

210-214 °C(lit.)

Boiling point:

421.17°C (rough estimate)

Density 

1.0823 (rough estimate)

bulk density

150kg/m3

refractive index 

1.6200 (estimate)

storage temp. 

2-8°C

solubility 

acetic acid: 50mg/mL, colorless to very faintly brown

form 

Powder

pka

10.78±0.20(Predicted)

color 

White

Water Solubility 

Soluble in alcohol. Insoluble in water.

BRN 

2388004

CAS DataBase Reference

370-81-0(CAS DataBase Reference)

EPA Substance Registry System

Ethanedioic acid, bis(cyclohexylidenehydrazide) (370-81-0)

Safety Information

Hazard Codes 

Xn

Risk Statements 

21/22

Safety Statements 

24/25-2

WGK Germany 

3

RTECS 

RO2520000

TSCA 

Yes

HS Code 

29280090

MSDS

• Language:English Provider:Bis(cyclohexanone)oxaldihydrazone
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Bis(cyclohexanone)oxaldihydrazone Usage And Synthesis

Chemical Properties

white powder

Uses

Bis(cyclohexanone) oxaldihydrazone is used in the quantitative spectroscopic determination of copper. It is also essential for the experimental study of mitochondrial metabolism. It is used to study the human demyelinating diseases such as multiple sclerosis and components of neuroinflammation. Further, it acts as ligand and catalyzes Ullmann-type C-N bond forming reactions in the presence of copper salt.

Definition

ChEBI: Cuprizon is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.

Biological Activity

Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell death, thereby leading to demyelination, astrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum.

Safety Profile

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also OXALATES.

Bis(cyclohexanone)oxaldihydrazone(370-81-0)Related Product Information

• Cyclohexanone
• Mefenacet
• Oxalic acid
• Bismaleimide
• DIFLUFENZOPYR
• Sodium diethyldithiocarbamate
• Glycine
• Folic acid
• Citric acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Dithizone
• Ketoketal
• Oxamic hydrazide
• ETHYLENEDIAMINE MONOHYDRATE
• Methylhydrazine
• ETHYLHYDRAZINE
• Formylhydrazine
• Dichlormide