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Boc-His(Trt)-Aib-OH

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Boc-His(Trt)-Aib-OH Basic information

Product Name:
Boc-His(Trt)-Aib-OH
Synonyms:
  • (Tert-Butoxy)Carbonyl L-His(Trt)-Aib-OH
  • BOC-L-HIS(TRT)-AIB-OH
  • 2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanamido]-2-methylpropanoic acid
  • (S)-2-(2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoic acid
  • Boc-His(Trt)-Aib-OH
  • BOC-L-HIS(TRT)-AIB-OH,Semaglutide sidechain
  • (S)-2-[2-(Boc-amino)-3-(1-trityl-4-imidazolyl)propanamido]-2-methylpropanoic Acid
  • Semaglutide Chain Chian
CAS:
2061897-68-3
MF:
C34H38N4O5
MW:
582.7
Mol File:
2061897-68-3.mol
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Boc-His(Trt)-Aib-OH Chemical Properties

Boiling point:
789.3±60.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
pka
3.43±0.10(Predicted)
color 
White to Off-White
InChIKey
POZCMPSLNOUKQN-NPFCIKOQNA-N
SMILES
C(C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)N1C=NC(C[C@H](NC(=O)OC(C)(C)C)C(=O)NC(C)(C)C(=O)O)=C1 |&1:24,r|
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Boc-His(Trt)-Aib-OH Usage And Synthesis

Uses

Boc-His(Trt)-Aib-OH is a peptide that can be synthesized from Boc-His(Trt)-OH (32926-43-5).

Biosynthesis

Boc-His(Trt)-Aib-OH is a peptide that can be synthesized from Boc-His(Trt)-OH.

Synthesis

4.3 g of Boc-L-His(Trt)-Aib-OBzl were dissolved in 30 ml THF and 3 ml of ethyl acetate. 0.43 g of the hydrogenation catalyst Pd/C (5%) was added and the compound was hydrogenated at 30° C for 2 h at atmospheric hydrogen pressure using a balloon. The catalyst is filtered oil and washed with 30 ml of ethyl acetate. The solution was stirred for several hours until precipitation occurred. The precipitate is filtered off and dried under vacuum to obtain 2.45 g of Boc-His(Trt)-Aib-OH.

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