Fmoc-8-amino-3,6-dioxaoctanoic acid
Fmoc-8-amino-3,6-dioxaoctanoic acid Basic information
- Product Name:
- Fmoc-8-amino-3,6-dioxaoctanoic acid
- Synonyms:
-
- Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA
- Fmoc-PEG2-acetic acid
- {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC)
- Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem
- 1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid
- 9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
- 8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID
- 8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID
- CAS:
- 166108-71-0
- MF:
- C21H23NO6
- MW:
- 385.41
- EINECS:
- 200-111-8
- Product Categories:
-
- peg
- 166108-71-0
- ADC Linker
- Mol File:
- 166108-71-0.mol
Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties
- Melting point:
- 90-92℃
- Boiling point:
- 631.4±45.0 °C(Predicted)
- Density
- 1.265±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 3.40±0.10(Predicted)
- form
- Crystalline Powder
- color
- White
- InChI
- InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
- InChIKey
- XQPYRJIMPDBGRW-UHFFFAOYSA-N
- SMILES
- C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2
- CAS DataBase Reference
- 166108-71-0(CAS DataBase Reference)
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29189900
MSDS
- Language:English Provider:SigmaAldrich
Fmoc-8-amino-3,6-dioxaoctanoic acid Usage And Synthesis
Description
Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical Properties
White solid
Uses
Hydrophillic spacer group.
Uses
8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.
Application
Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.
Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials
Raw materials
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Fmoc-8-amino-3,6-dioxaoctanoic acid(166108-71-0)Related Product Information
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