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Isoprenaline sulphate

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Isoprenaline sulphate Basic information

Product Name:
Isoprenaline sulphate
Synonyms:
  • 1-(3,4-DIHYDROXYPHENYL)-2-ISOPROPYLAMINOETHANOL HEMISULFATE SALT
  • Isoprenaline sulfuric acid
  • Isoproterenol sulfuric acid
  • 4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol
  • 1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol sulfate (2:1)
  • dl-a-3,4-Dihydroxyphenyl-b-iso-propylaminoethanol sulfate
  • dl-Isoprenaline sulfate
  • dl-Isoproterenol sulfate
CAS:
299-95-6
MF:
2C11H17NO3.H2O4S
MW:
520.6
EINECS:
206-085-2
Mol File:
299-95-6.mol
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Isoprenaline sulphate Chemical Properties

Melting point:
180 °C
Water Solubility 
almost transparency
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Safety Information

Risk Statements 
22
Safety Statements 
44
RTECS 
DO2273000
HS Code 
29072990
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Isoprenaline sulphate Usage And Synthesis

Originator

Isonorin,Smith, Miller and Patch,US,1949

Uses

Bronchodilator.

Manufacturing Process

As described in US Patent 2,308,232, 100 g 3,4-dihydroxy-ω- chloroacetophenone, 200 cc ethyl alcohol and 200 cc of about 50% aqueous isopropylamine solution are boiled during 3 hours on the water bath with the use of a reflux condenser, whereupon neutralizing with diluted sulfuric acid is carried out and the sulfate, obtained upon cooling, from alcohol of 50% is recrystallized; its MP is 245°C.
21 g 3,4-dihydroxy-ω-isopropylaminoacetophenone sulfate are hydrogenated with 50 cc methyl alcohol and 50 cc water, 0.5 g carbon and 3 cc palladium chloride solution of 2%. After 2 hours the hydrogen absorption comes to a standstill, after the theoretical quantity of hydrogen has been absorbed. After concentrating, the isopropylaminomethyl-(3,4-dihydroxyphenyl)carbinolsulfate crystallizes out. It has a MP of 180°C after refining.

brand name

Medihaler-ISO (3M Pharmaceuticals).

Therapeutic Function

Bronchodilator

Isoprenaline sulphateSupplier

J & K SCIENTIFIC LTD.
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Maya High Purity Chemicals
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