Isoprenaline sulphate Chemical Properties

Melting point:

180 °C

form 

powder to crystal

color 

White to Almost white

Water Solubility 

almost transparency

Safety Information

Risk Statements 

22

Safety Statements 

44

RTECS 

DO2273000

HS Code 

29072990

Toxicity

dog,LD50,intravenous,50mg/kg (50mg/kg),Drugs in Japan Vol. 6, Pg. 75, 1982.

Isoprenaline sulphate Usage And Synthesis

Originator

Isonorin,Smith, Miller and Patch,US,1949

Uses

Bronchodilator.

Manufacturing Process

As described in US Patent 2,308,232, 100 g 3,4-dihydroxy-ω- chloroacetophenone, 200 cc ethyl alcohol and 200 cc of about 50% aqueous isopropylamine solution are boiled during 3 hours on the water bath with the use of a reflux condenser, whereupon neutralizing with diluted sulfuric acid is carried out and the sulfate, obtained upon cooling, from alcohol of 50% is recrystallized; its MP is 245°C.
21 g 3,4-dihydroxy-ω-isopropylaminoacetophenone sulfate are hydrogenated with 50 cc methyl alcohol and 50 cc water, 0.5 g carbon and 3 cc palladium chloride solution of 2%. After 2 hours the hydrogen absorption comes to a standstill, after the theoretical quantity of hydrogen has been absorbed. After concentrating, the isopropylaminomethyl-(3,4-dihydroxyphenyl)carbinolsulfate crystallizes out. It has a MP of 180°C after refining.

brand name

Medihaler-ISO (3M Pharmaceuticals).

Therapeutic Function

Bronchodilator

Isoprenaline sulphate(299-95-6)Related Product Information

• Isoproterenol
• FERROUS SULFATE
• Magnesium sulfate
• Norepinephrine
• Copper(II) sulfate
• SULFATE STANDARD
• (-)-ISOPROTERENOL HYDROCHLORIDE
• Racecadotril
• Potassium persulfate
• Colistin sulfate
• calcium sulfate
• Racanisodamine
• CHLOROPHOSPHONAZO III
• Sodium sulfate
• Zinc sulphate
• L(-)-Epinephrine
• Atropine sulfate
• Ferrous sulfate monohydrate