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(-)-ISOPROTERENOL HYDROCHLORIDE

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(-)-ISOPROTERENOL HYDROCHLORIDE Basic information

Product Name:
(-)-ISOPROTERENOL HYDROCHLORIDE
Synonyms:
  • (r)-isoprenalinehydrochloride
  • isopropylnoradrenaline
  • isoprotemol
  • (-)-N-ISOPROPYL-L-NORADRENALIN HYDROCHLO RIDE
  • Off-whitecrystalsHCl
  • 1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride (9CI)
  • 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride, (R)-
  • Benzyl alcohol, 3,4-dihydroxy-a-[(isopropylamino)methyl]-, hydrochloride, (-)- (8CI)
CAS:
5984-95-2
MF:
C11H18ClNO3
MW:
247.72
Mol File:
5984-95-2.mol
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(-)-ISOPROTERENOL HYDROCHLORIDE Chemical Properties

Melting point:
175 °C (dec.)(lit.)
storage temp. 
−20°C
form 
Solid
color 
White to off-white
Water Solubility 
soluble (50 mg/ml: H2O)
BRN 
6077193
InChI
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
InChIKey
IROWCYIEJAOFOW-UHFFFAOYSA-N
SMILES
CC(C)NCC(O)C1C=CC(O)=C(O)C=1.[H]Cl
CAS DataBase Reference
5984-95-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
DO1926000
F 
10

MSDS

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(-)-ISOPROTERENOL HYDROCHLORIDE Usage And Synthesis

Uses

(-)-Isoproterenol hydrochloride is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator.

Biochem/physiol Actions

Isoproterenol hydrochloride is useful in post transplantal organ recovery. It exhibits ionotropic and chronotropic effects. With respect to donor heart recovery, isoproterenol hydrochloride decreases peripheral and systemic vascular resistance. Isoproterenol also increases the heart rate.

in vivo

(-)-Isoproterenol hydrochloride (85 mg/kg; s.c.; daily for two consecutive days) induces ventricular remodeling (VR) in rat[1].

Animal Model:180-200 g, 6-7 weeks, Healthy male Sprague Dawley rats[1]
Dosage:85 mg/kg
Administration:S.c.; daily for two consecutive days
Result:Decreased the systolic blood pressure (SBP) levels, increased LV weight index (LVWI) and heart weight index (HWI), the average cross section area markedly increased, significant increased in the levels of NT-proBNP in the myocardium.

(-)-ISOPROTERENOL HYDROCHLORIDESupplier

3B Pharmachem (Wuhan) International Co.,Ltd. Gold
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821-50328103-801 18930552037
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3bsc@sina.com
Zhejiang Boxiao Bio-Pharmaceutical Co., Ltd. Gold
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0571-63280982
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Syntechem Co.,Ltd
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
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marketing_china@spectrumchemical.com
Wuhan DKY Technology Co.,Ltd.
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027-27-81302488 15972195220
Email
info@dkybpc.com
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