DL-Octopamine hydrochloride Chemical Properties

Melting point:

~170 °C (dec.)(lit.)

Boiling point:

290℃[at 101 325 Pa]

Density 

1.39[at 20℃]

vapor pressure 

0.002Pa at 20℃

storage temp. 

2-8°C

solubility 

H₂O: soluble

form 

solid

color 

white or off-white

Water Solubility 

soluble

Merck 

13,6791

BRN 

3915414

Stability:

Stable.

LogP

-2.6 at 20.1℃

CAS DataBase Reference

770-05-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

36-37/39-26

RIDADR 

3249

WGK Germany 

3

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:1-(4-Hydroxyphenyl)-2-amino-ethanol hydrochloride
• Language:English Provider:SigmaAldrich

DL-Octopamine hydrochloride Usage And Synthesis

Chemical Properties

DL-Octopamine hydrochloride is a light-yellow crystalline solid and derived from the dried young fruit of Citrus aurantium L., a plant of the Rutaceae family,It is soluble to 10 mg/ml in PBS, 10 mg/ml in EtOH, and 12 mg/ml in DMSO & DMF. Its use is similar to that of Synflorin HCL. It is an adrenergic alpha-receptor stimulant with vasoconstrictive and hypertensive effects.

Originator

Norfen,Morishita, Japan ,1975

Uses

Octopamine HCL has the ability to halt catabolism of proteinaceous tissues. It is very important while losing weight to maximize adipose loss while minimizing the loss of muscle and other lean body tissue. Octopamine Hcl (norepinephrine) is best known as an effective ephedrine alternative, claiming to boost energy while reduce weight in bodybuilding industry for weight loss purpose. In addition, many users believe octopamine hcl is a good nootropic compound that makes our brain easy to focus, enhances motivation as a wakefulness promoter.

Uses

A biogenic amine that is the phenol analog of Noradrenaline. It is a neurosecretory product found in several vertebrates and invertebrates. Adrenergic.

Manufacturing Process

A solution of 33 grams of anhydrous aluminum chloride in 60 grams of nitrobenzene, to which a mixture of 14 grams of phenol and 9.3 grams of hydrochloride of amino-acetonitrile was added, had dry hydrochloric acid gas introduced into it for 3 hours, while stirring and cooling to keep the temperature between 20° and 30°C. The reaction mixture was then poured, with cooling, into 70 cc of water and the deposit obtained was sucked off, washed with acetone and dissolved in 300 cc of water. The solution thus prepared was decolorized with carbon, 50 grams of 30% sodium citrate solution was added to it, and then it was made slightly alkaline with ammonia. Thereupon hydroxy-4'-phenyl-1-amino-2-ethanone crystallized out in the form of leaflets. The yield was 7.7 grams.
The hydrochloride of this base, obtained by evaporation to dryness of a solution of the base in dilute hydrochloric acid and subsequent treatment of the residue with ethyl alcohol and acetone, had a chlorine content of 18.84%, (calculated, 18.90%).
This hydrochloride, on being dissolved in water and hydrogenated with hydrogen and a nickel catalyst, gave a good yield of hydrochloride of hydroxy4'-phenyl-1-amino-2-ethanol melting, after crystallization from a mixture of ethyl alcohol and butanone-2, at from 177° to 179°C with decomposition

Therapeutic Function

Hypertensive

General Description

Octopamine is a biogenic amine, which functions as a neurotransmitter, neuromodulator and neurohormone. It is used to regulate various behaviors, such as learning, memory and aggression. Octopamine is present in mammalian tissues, human urine and invertebrates.

Flammability and Explosibility

Not classified

Biological Activity

Invertebrate biogenic amine neurotransmitter, related to noradrenalin, that is an adrenoceptor agonist. Stimulates lipolysis in mammalian adipocytes via activation of β 3 receptors. Has dual effect on glucose transport in adipocytes: inhibits transport via β 3 receptor activation but stimulates transport when oxidised by MAO. Also activates human α 2A receptors, inhibiting subsequent cAMP production.

Mode of action

Octopamine hydrochloride is an invertebrate biogenic amine neurotransmitter, related to noradrenalin, that is an adrenoceptor (AR) agonist. Octopamine hydrochloride stimulates lipolysis in mammalian adipocytes via activation of β3-AR receptors. Has dual effect on glucose transport in adipocytes: inhibits transport via β3-AR receptor activation but stimulates transport when oxidised by MAO. Also activates human α2A-AR receptors, inhibiting subsequent cAMP production.

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