Basic information Safety Supplier Related

Octopamine

Basic information Safety Supplier Related

Octopamine Basic information

Product Name:
Octopamine
Synonyms:
  • 4-(2-AMINO-1-HYDROXY-ETHYL)-PHENOL
  • ALPHA-(AMINOMETHYL)-PARA-HYDROXYBENZYLALCOHOL
  • PARA-OCTOPAMINE
  • p-Octopamine
  • D-(-)-octopamine
  • ND 50
  • ND-50
  • α-(Aminomethyl)-p-hydroxybenzyl alcohol
CAS:
104-14-3
MF:
C8H11NO2
MW:
153.18
EINECS:
203-179-5
Mol File:
104-14-3.mol
More
Less

Octopamine Chemical Properties

Melting point:
157-158 °C
Boiling point:
276.1°C (rough estimate)
Density 
1.1577 (rough estimate)
refractive index 
1.5010 (estimate)
pka
pKa 8.88 (Uncertain);9.53 (Uncertain)
CAS DataBase Reference
104-14-3(CAS DataBase Reference)
More
Less

Safety Information

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 oral in rat: 1240mg/kg
More
Less

Octopamine Usage And Synthesis

Description

An alkaloid found in annual rye grass, this base has been suggested as a possible precursor of annuloline (q.v.).

Originator

Norfen,Morishita, Japan ,1975

Uses

Octopamine is a biogenic monoamine structurally related to Noradrenaline (N661038), it acts as a neurohormone, neuromodulator and a neurotransmitter in invertebrates.

Manufacturing Process

A solution of 33 grams of anhydrous aluminum chloride in 60 grams of nitrobenzene, to which a mixture of 14 grams of phenol and 9.3 grams of hydrochloride of amino-acetonitrile was added, had dry hydrochloric acid gas introduced into it for 3 hours, while stirring and cooling to keep the temperature between 20° and 30°C. The reaction mixture was then poured, with cooling, into 70 cc of water and the deposit obtained was sucked off, washed with acetone and dissolved in 300 cc of water. The solution thus prepared was decolorized with carbon, 50 grams of 30% sodium citrate solution was added to it, and then it was made slightly alkaline with ammonia. Thereupon hydroxy-4'-phenyl-1-amino-2-ethanone crystallized out in the form of leaflets. The yield was 7.7 grams.
The hydrochloride of this base, obtained by evaporation to dryness of a solution of the base in dilute hydrochloric acid and subsequent treatment of the residue with ethyl alcohol and acetone, had a chlorine content of 18.84%, (calculated, 18.90%).
This hydrochloride, on being dissolved in water and hydrogenated with hydrogen and a nickel catalyst, gave a good yield of hydrochloride of hydroxy4'-phenyl-1-amino-2-ethanol melting, after crystallization from a mixture of ethyl alcohol and butanone-2, at from 177° to 179°C with decomposition

Therapeutic Function

Hypertensive

References

Hardwick, Axelrod, Plant Physiol., 44, 1745 (1969)

OctopamineSupplier

Syntechem Co.,Ltd
Tel
Please Email
Email
info@syntechem.com
Shanghai Fuhe Chemistry Technology Co., Ltd.
Tel
0086-21-67651709
Email
cfx759@hotmail.com
BOC Sciences
Email
info@bocsci.com
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988
Email
sales@ncebiomed.com
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com