Ethyl 2-hydroxybenzoate Chemical Properties

Melting point:

1 °C (lit.)

Boiling point:

234 °C (lit.)

Density 

1.131 g/mL at 25 °C (lit.)

vapor pressure 

0.05 mm Hg ( 25 °C)

refractive index 

n20/D 1.522(lit.)

FEMA 

2458 | ETHYL SALICYLATE

Flash point:

225 °F

storage temp. 

Store below +30°C.

solubility 

0.25g/l

form 

Liquid

pka

9.93±0.10(Predicted)

color 

Clear colorless to pale yellow

Odor

at 100.00 %. sweet wintergreen mint floral spicy balsam

Odor Type

minty

explosive limit

1.1%(V)

Water Solubility 

slightly soluble

Merck 

14,3850

JECFA Number

900

BRN 

907659

Dielectric constant

8.6（21℃）

InChIKey

GYCKQBWUSACYIF-UHFFFAOYSA-N

LogP

3.07 at 21.9℃

CAS DataBase Reference

118-61-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzoic acid, 2-hydroxy-, ethyl ester(118-61-6)

EPA Substance Registry System

Ethyl salicylate (118-61-6)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/38-52/53

Safety Statements 

26-36

WGK Germany 

1

RTECS 

VO3000000

TSCA 

Yes

HS Code 

29182390

Toxicity

LD50 orally in Rabbit: 1320 mg/kg LD50 dermal Rabbit > 5000 mg/kg

MSDS

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Ethyl 2-hydroxybenzoate Usage And Synthesis

Description

Ethyl 2-hydroxdybenzoate is also known as Ethyl salicylate, which a kind of ester formed through the condensation between salicylic acid and ethanol. It can be used as a perfumery, artificial essence flavoring agent and used in cosmetics. It can also be used as analgesics, anti-inflammatory and antipyretic agents.

Chemical Properties

clear colourless to pale yellow liquid

Chemical Properties

Ethyl salicylate is the ester formed by the condensation of salicylic acid and ethanol. It is a clear liquid that is sparingly soluble in water, but soluble in alcohol and ether. It has a pleasant odor resembling winter green and is used in perfumery and artificial flavors.

Chemical Properties

Ethyl salicylate has a characteristic aromatic odor similar to wintergreen. It tends to darken on exposure to light and air.

Occurrence

Reported found in raspberry, tomato, currants, rum, whiskey, red wine, plum brandy, Cape gooseberry, Feijoa fruit, papaya and scotch.

Uses

manufacture of artificial perfumes.

Uses

Ethyl salicylate is a non-steroidal analgesic, anti-inflammatory and antirrheumatic drug. Its complexation with β-cyclodextrin was studied using reversed-phase liquid chromatography.

Uses

Ethyl salicylate may be used as an analytical standard for the determination of the analyte in biological fluids and topical formulation by chromatography-based techniques.

Definition

ChEBI: Ethyl salicylate is a hydroxybenzoic acid.

Production Methods

Ethyl salicylate is found naturally in currants and strawberries . It is manufactured commercially by the esterification of salicylic acid with ethyl alcohol.

Preparation

Ethyl 2-hydroxybenzoate is prepared by esterification of salicylic acid with ethyl alcohol and concentrated H2SO4 at 100°C in the presence of aluminum sulfate; by heating to the boil an alkaline solution of salicylic acid and ethyl p-toluenesulfonate.

Taste threshold values

Taste characteristics at 10 ppm: sweet, wintergreen, spicy and anisic.

General Description

Ethyl salicylate was hydrolysed to salicylic acid by the use of an extractive electrospray ionisation (EESI) device.

Flammability and Explosibility

Not classified

References

Sheu, Yaw-Wen, and Chein-Hsiun Tu. "Densities and viscosities of binary mixtures of ethyl acetoacetate, ethyl isovalerate, methyl benzoate, benzyl acetate, ethyl salicylate, and benzyl propionate with ethanol at T=(288.15, 298.15, 308.15, and 318.15) K." Journal of Chemical & Engineering Data 51.2 (2006): 545-553.
Filippa, Mauricio, Matías I. Sancho, and Estela Gasull. "Encapsulation of methyl and ethyl salicylates by β-cyclodextrin: HPLC, UV–vis and molecular modeling studies." Journal of pharmaceutical and biomedical analysis 48.3 (2008): 969-973.

Ethyl 2-hydroxybenzoate(118-61-6)Related Product Information

• Benzyl salicylate
• Isobutyl salicylate
• 2-HYDROXY-3-ISOPROPYLBENZOIC ACID
• Methyl salicylate
• Phenyl salicylate
• Sodium salicylate
• Amyl salicylate
• 2-Ethylhexyl salicylate
• isodecyl salicylate
• Methyl salicylate
• (+)-Bicuculline
• PHENETHYL SALICYLATE
• Ethyl 2-hydroxybenzoate
• Butyl salicylate
• Hexyl salicylate
• ACETYLSALICYLIC ANHYDRIDE
• Isopropyl salicylate
• 2-Methoxybenzoic acid ethyl ester