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Ethyl p-toluenesulfonate

Basic information Safety Supplier Related

Ethyl p-toluenesulfonate Basic information

Product Name:
Ethyl p-toluenesulfonate
Synonyms:
  • 4-methyl-benzenesulfonicaciethylester
  • Benzenesulfonicacid,4-methyl-,ethylester
  • Ethyl 4-methylbenzenesulfonate
  • Ethyl ester of p-Toluenesulfonic acid
  • Ethyl para-toluenesulfonate
  • Ethyl p-TS
  • Ethyl toluene-4-sulfonate
  • Ethylester kyseliny p-toluensulfonove
CAS:
80-40-0
MF:
C9H12O3S
MW:
200.25
EINECS:
201-276-7
Product Categories:
  • Sulphur Derivatives
  • Organic Building Blocks
  • Sulfur Compounds
  • Tosylates
  • bc0001
Mol File:
80-40-0.mol
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Ethyl p-toluenesulfonate Chemical Properties

Melting point:
29-33 °C(lit.)
Boiling point:
158-162 °C10 mm Hg(lit.)
Density 
1.174 g/mL at 25 °C(lit.)
vapor pressure 
0.6 hPa (14 °C)
refractive index 
n20/D 1.511(lit.)
Flash point:
316 °F
storage temp. 
2-8°C
solubility 
1.24g/l
form 
Liquid After Melting
color 
Clear colorless to pale brown
Water Solubility 
Insoluble
Sensitive 
Moisture Sensitive
Merck 
14,3858
BRN 
611213
CAS DataBase Reference
80-40-0(CAS DataBase Reference)
NIST Chemistry Reference
Benzenesulfonic acid, 4-methyl-, ethyl ester(80-40-0)
EPA Substance Registry System
Benzenesulfonic acid, 4-methyl-, ethyl ester (80-40-0)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-40-22
Safety Statements 
26-45-36/37/39
RIDADR 
UN2811
WGK Germany 
3
RTECS 
XT6825000
21
Autoignition Temperature
500 °C
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29041000
Hazardous Substances Data
80-40-0(Hazardous Substances Data)

MSDS

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Ethyl p-toluenesulfonate Usage And Synthesis

Chemical Properties

Clear colorless to brownish liquid after melting

Uses

Ethyl p-toluenesulfonate was used to develop an extraction method for methyl and ethyl esters of various sulfonic acids in active pharmaceutical ingredients using solid-phase micro extraction coupled to GC/MS in the selected ion monitoring mode. It was used in a study to develop a fast and accurate method for determination of residues of some common alkylating agents employed in drug synthesis by in situ derivatization-headspace-gas chromatography-mass spectrometry.

Uses

Ethyl p-toluenesulfonate can be used in the manufacture of organic synthesis, and also can be used as intermediate of methylation reagent and sensitive material. It also is flexibilizer of cellulose acetate.

Uses

For ethylation.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 34, p. 2710, 1986 DOI: 10.1248/cpb.34.2710
The Journal of Organic Chemistry, 39, p. 3454, 1974 DOI: 10.1021/jo00937a050

Safety Profile

Moderately toxic by subcutaneous and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidzing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits hlghly toxic fumes of SOx. See also SULFONATES and ESTERS.

Ethyl p-toluenesulfonate Preparation Products And Raw materials

Preparation Products

Raw materials

Ethyl p-toluenesulfonateSupplier

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