H-8 DIHYDROCHLORIDE Chemical Properties

Melting point:

221-222℃ (methanol water )

storage temp. 

2-8°C

solubility 

ethanol: 25 mg/mL, clear, colorless

form 

Lyophilized

color 

White to Off-White

CAS DataBase Reference

113276-94-1(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

29334990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

H-8 DIHYDROCHLORIDE Usage And Synthesis

Description

The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with K_i values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC₅₀ values of 47 and 6.2 μM, respectively.

Chemical Properties

white to off-white crystalline solid

Uses

Active inhibitor of cyclic-nucleotide-dependent protein kinases.

Biochem/physiol Actions

cAMP and cGMP-dependent protein kinase inhibitor.

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