Basic information Safety Supplier Related

H-8 DIHYDROCHLORIDE

Basic information Safety Supplier Related

H-8 DIHYDROCHLORIDE Basic information

Product Name:
H-8 DIHYDROCHLORIDE
Synonyms:
  • 5-IsoquinolinesulfonaMide,N-[2-(MethylaMino)ethyl]-, hydrochloride (1:2)
  • H-8 DIHYDROCHLORIDE
  • H-8 HYDROCHLORIDE
  • H-8
  • N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL
  • N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, DI-HCL SALT
  • N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE
  • N-(2-[METHYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
CAS:
113276-94-1
MF:
C12H17Cl2N3O2S
MW:
338.25
Mol File:
113276-94-1.mol
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H-8 DIHYDROCHLORIDE Chemical Properties

Melting point:
221-222℃ (methanol water )
storage temp. 
2-8°C
solubility 
ethanol: 25 mg/mL, clear, colorless
form 
Lyophilized
color 
White to Off-White
CAS DataBase Reference
113276-94-1(CAS DataBase Reference)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29334990

MSDS

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H-8 DIHYDROCHLORIDE Usage And Synthesis

Description

The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 μM, respectively.

Chemical Properties

white to off-white crystalline solid

Uses

Active inhibitor of cyclic-nucleotide-dependent protein kinases.

Biochem/physiol Actions

cAMP and cGMP-dependent protein kinase inhibitor.

H-8 DIHYDROCHLORIDESupplier

J & K SCIENTIFIC LTD.
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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3B Pharmachem (Wuhan) International Co.,Ltd.
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Chemsky(shanghai)International Co.,Ltd.
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Thermo Fisher Scientific
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800-810-5118
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cnchemical@thermofisher.com