1-(3-METHYLPHENYL)PIPERAZINE DIHYDROCHLORIDE HYDRATE Chemical Properties

Melting point:

195-202 °C

form 

powder to crystal

color 

White to Almost white

CAS DataBase Reference

13078-13-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

36/37/38-24-22

Safety Statements 

45-36/37/39-26

HS Code 

2933.59.8000

MSDS

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1-(3-METHYLPHENYL)PIPERAZINE DIHYDROCHLORIDE HYDRATE Usage And Synthesis

Uses

1-(3-methylphenyl)piperazine dihydrochloride is a piperazine derivative and can be used as a pharmaceutical intermediate.

Synthesis

In a 100 ml flask, diethanolamine (10 g) was dissolved in chloroform (40 ml), and a chloroform (20 ml) solution of dichlorosulfoxide (2.6 ml) was added slowly and dropwise at room temperature. Reacted for 7h, the reaction was complete, spun dry, chloroform was added additionally, spun dry again and the dichlorosulfoxide was evaporated to dryness. It was dried to give 14 g of white solid (??-chloroethyl)amine hydrochloride in 85% yield, mp: 214.1-215.2??C (literature value > 215-216??C).

1.58g (10mmol) of IX was added to 10ml of n-butanol with 1mol of aniline derivative and reacted at 180??C for 30min in microwave. at the end of the reaction it was allowed to stand and cooled to precipitate crystals. The filter cake was washed with a small amount of dichloromethane and dried under vacuum to obtain white crystals of 1-(3-methylphenyl)piperazine dihydrochloride in 45-54% yield.

1-(3-METHYLPHENYL)PIPERAZINE DIHYDROCHLORIDE HYDRATE(13078-13-2)Related Product Information

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