1,4-Diaminobutane dihydrochloride Chemical Properties

Melting point:

280 °C (dec.)(lit.)

Boiling point:

265.47°C (rough estimate)

Density 

1.2524 (rough estimate)

vapor pressure 

436 Pa ( 25 °C)

refractive index 

1.6300 (estimate)

storage temp. 

Store below +30°C.

solubility 

H₂O: 100 mg/mL

form 

powder

color 

White

explosive limit

0.7-11.2% (v/v)

biological source

synthetic (organic)

Water Solubility 

almost transparency

Sensitive 

Hygroscopic

Merck 

14,7947

BRN 

3906680

Stability:

Stable, but hygroscopic. Substances to be avoided: strong oxidizing agents. Combustible.

Cosmetics Ingredients Functions

NOT REPORTED

InChI

1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H

InChIKey

XXWCODXIQWIHQN-UHFFFAOYSA-N

SMILES

Cl[H].Cl[H].NCCCCN

CAS DataBase Reference

333-93-7(CAS DataBase Reference)

EPA Substance Registry System

1,4-Diaminobutane dihydrochloride (333-93-7)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

EJ7280000

TSCA 

TSCA listed

HS Code 

29212900

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 2 Inhalation
Acute Tox. 3 Dermal
Acute Tox. 4 Oral
Eye Dam. 1
Skin Corr. 1B

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1,4-Diaminobutane dihydrochloride Usage And Synthesis

Chemical Properties

white powder

Uses

Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture, retinal ganglion cell culture and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay.

General Description

Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour. It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase. Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.

Biochem/physiol Actions

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.

Synthesis

A mixture of 880 kg of 1,4-butanediamine and 4990 kg of toluene was prepared in the salt-forming reactor and stirred well. Then, the temperature inside the reactor was controlled at 15??C and the reaction pressure was 0.12 MPa, and the hydrogen chloride gas was started to be passed into the reactor through the hydrogen chloride gas blow-in tube at a rate of 370 Nm3/h, and the hydrogen chloride passage was stopped after 3 hours, and the diamine dihydrochloride solution was obtained, and the hydrochloride salt obtained was filtered and dried in a triplex machine to obtain the 1,4-butanediamine dihydrochloride solid.

Purification Methods

Crystallise the salt from EtOH/H2O. [Beilstein 4 IV 1284.]

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