QUINACRINE MUSTARD DIHYDROCHLORIDE
QUINACRINE MUSTARD DIHYDROCHLORIDE Basic information
- Product Name:
- QUINACRINE MUSTARD DIHYDROCHLORIDE
- Synonyms:
-
- 9-(4-bis(2-chloroethyl)amino-1-methylbutylamino)-6-chloro-2-methoxy-acridin
- 9-(4-bis(2-chloroethyl)amino-1-methylbutylamino)-6-chloro-2-methoxyacridine
- icr10
- quinacrinemustard
- N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine dihydrochloride
- QUINACRINE MUSTARD DIHYDROCHLORIDE, FOR FLUORESCENCE
- QUINACRINE MUSTARD DIHYDROCHLORIDE 90+%
- 2-methoxy-6-chloro-9-(4-bis[β-chloroethyl]amino-1-methylbutylamino)acridine dihydrochloride
- CAS:
- 4213-45-0
- MF:
- C23H30Cl5N3O
- MW:
- 541.77
- EINECS:
- 224-140-9
- Mol File:
- 4213-45-0.mol
QUINACRINE MUSTARD DIHYDROCHLORIDE Chemical Properties
- storage temp.
- −20°C
- solubility
- Chloroform: soluble
- form
- A crystalline solid
- color
- Light yellow to yellow
- Water Solubility
- Water: soluble
- BRN
- 3819822
- InChIKey
- JETDZFFCRPFPDH-UHFFFAOYSA-N
- SMILES
- C1(NC(C)CCCN(CCCl)CCCl)C2C=CC(Cl)=CC=2N=C2C=CC(OC)=CC=12.Cl.Cl
- CAS DataBase Reference
- 4213-45-0
- EPA Substance Registry System
- 1,4-Pentanediamine, N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxy-9-acridinyl)-, dihydrochloride (4213-45-0)
Safety Information
- Hazard Codes
- T
- Risk Statements
- 46-23/25-42/43
- Safety Statements
- 53-22-36/37/39-45
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- AR7580000
- HazardClass
- 6.1(b)
- PackingGroup
- III
QUINACRINE MUSTARD DIHYDROCHLORIDE Usage And Synthesis
Description
Quinacrine mustard is a fluorescent DNA-intercalating agent. It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs. Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography. It displays excitation/emission maxima of 425/480 nm, respectively.
Uses
Quinacrine mustard dihydrochloride is a fluorescent probe.
Safety Profile
Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. Corrosive. When heated to decomposition it emits very toxic fumes of Cland NOx. See also QUINACRINE MUSTARD.
References
[1] T. CASPERSSON . Chemical differentiation along metaphase chromosomes[J]. Experimental cell research, 1968, 49 1: Pages 219-222. DOI: 10.1016/0014-4827(68)90538-7
[2] J R ELLISON H J B. Quinacrine fluorescence of specific chromosome regions. Late replication and high A: T content in Samoaia leonensis.[J]. Chromosoma, 1972, 36 4: 375-390. DOI: 10.1007/bf00336794
[3] B WEISBLUM P L D H. Quinacrine, a chromosome stain specific for deoxyadenylate-deoxythymidylaterich regions in DNA.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1972, 69 3: 629-632. DOI: 10.1073/pnas.69.3.629
[4] CHEN R F. Fluorescence of quinacrine mustard conjugated to proteins[J]. Archives of biochemistry and biophysics, 1976, 172 1: Pages 39-50. DOI: 10.1016/0003-9861(76)90045-x
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QUINACRINE MUSTARD DIHYDROCHLORIDE(4213-45-0)Related Product Information
- QUINACRINE MUSTARD DIHYDROCHLORIDE
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- 4-(DIETHYLAMINO)BUTYLAMINE
- ACRIDINE HYDROCHLORIDE
- 2-Amino-5-diethylaminopentane
- Mepacrine hydrochloride
- Bis(2-chloroethyl)amine hydrochloride
- CHLOROQUINE
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- 7-Chloro-4-quinolinamine
- 9-AMINOACRIDINE
- 2-Diethylaminoethylchloride hydrochloride
- Chlormethine