ETHANOLAMINE HYDROCHLORIDE Chemical Properties

Melting point:

82-84 °C(lit.)

Density 

1.07g/cm3 at 20—25°C
1.12g/cm3 at 20—25°C

storage temp. 

Store below +30°C.

solubility 

DMSO (Slightly, Heated)

form 

Agglomerating Crystals

Specific Gravity

1.146

color 

White or slightly beige

PH

9—10

Odor

Odorless

pka

9.5(at 25℃)

Water Solubility 

almost transparency

Sensitive 

Hygroscopic

Merck 

14,3727

BRN 

3542892

Stability:

Hygroscopic

LogP

-1.308 (est)

CAS DataBase Reference

2002-24-6(CAS DataBase Reference)

EPA Substance Registry System

Ethanol, 2-amino-, hydrochloride (2002-24-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

1

RTECS 

KJ6370000

F 

3-10

TSCA 

Yes

HS Code 

29221100

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

ETHANOLAMINE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White or slightly beige agglomerating crystals

Uses

Ethanolamine hydrochloride has been used:

• in overnight incubation of the tips to attach primary amine groups at the tip surface
• in the preparation of DMEM (dulbecco′s modified eagle′s medium)/F-12 media to culture human epidermal growth factor receptor 2 (HER2) cells derived from MMTV-HER2 transgenic mouse mammary tumors
• to administer the cultures to study its effect on the endogenous phosphatidyl ethanolamine pool and autophagy process

Biochem/physiol Actions

Ethanolamine hydrochloride is utilized as a carbon and nitrogen source by bacteria that differs phylogenetically. It exists as phosphotidylethanolamine in the bacterial and mammalian cell membrane. Ethanolamine-ammonia lyase is responsible for the degradation of ethanolamine into acetaldehyde and ammonia. Ethanolamine is known to positively support lipid accumulation in photosynthetic organism model.

Synthesis

General procedure for the synthesis of ethanolamine hydrochloride from 2-aminoethanol: Reagents and reaction conditions: 36% concentrated hydrochloric acid, room temperature. Operating steps: 1. 15.0 g of 2-aminoethanol was weighed and added to three reaction flasks. 2. 27.0 g of 36% concentrated hydrochloric acid was added dropwise at a constant rate through a dropping funnel under stirring conditions, and the reaction temperature was controlled to be no more than 40 °C. 3. 3. after completion of the dropwise addition, the reaction mixture was continued to be stirred for 20 minutes until the pH was about 2 and the reaction was terminated. 4. remove water from the reaction system by concentration under reduced pressure until a very small amount of water remains. 5. A small amount of toluene was added and the residual water was further removed by azeotropic distillation. 6. The reaction mixture was rapidly cooled to give 23.7 g of a slightly light brown solid product, ethanolamine hydrochloride (M-07), in 99% yield.

Purification Methods

Recrystallise the salt from EtOH. It is deliquescent; store it dry. [Beilstein 4 IV 1406.]

References

[1] Bulletin des Societes Chimiques Belges, 1984, vol. 93, # 10, p. 903 - 912
[2] Patent: CN105585607, 2016, A. Location in patent: Paragraph 0107; 0108; 0109; 0110
[3] Green Chemistry, 2016, vol. 18, # 9, p. 2834 - 2842
[4] Green Chemistry, 2017, vol. 19, # 13, p. 3152 - 3163

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