CGS 15943 Chemical Properties

Melting point:

278-279 °C

Density 

1.72±0.1 g/cm3(Predicted)

storage temp. 

room temp

solubility 

DMSO: >16 mg/mL

form 

solid

pka

1.23±0.30(Predicted)

color 

white

Safety Information

WGK Germany 

3

CGS 15943 Usage And Synthesis

Uses

Potent adenosine receptor antagonist

Definition

ChEBI: A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosi e A2A receptors.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 1549, 1990 DOI: 10.1002/jhet.5570270605

Biological Activity

Potent adenosine receptor antagonist (K i values are 3.5, 4.2, 16 and 51 nM for human A 1 , A 2A , A 2B and A 3 receptors respectively). Orally active in vivo .

Biochem/physiol Actions

CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.

storage

Store at RT

CGS 15943(104615-18-1)Related Product Information

• 1H-1,2,4-Triazole-1-carboximidamide hydrochloride
• N,N-didemethylchlordimeform
• MRS 1220
• N-(4-Chlorophenyl)guanidine
• CGS 15943