Balsalazide disodium
Balsalazide disodium Basic information
- Product Name:
- Balsalazide disodium
- Synonyms:
-
- BALSALAZIDE DISODIUM SALT DIHYDRATE
- BALSALAZIDE DISODIUM DIHYDRATE
- BALSALAZIDE SODIUM
- BALSALZIDE DISODIUM
- (E)-5-[[4-[[(2-CARBOXYETHYL)AMINO]CARBONYL]PHENYL]AZO]-2-HYDROXYBENZOIC ACID, DISODIUM SALT, DIHYDRATE
- BALSALAZIDE DISODIUM 2-HYDRATE
- BALSALAZIDEDISODOUMSALT
- (E)-5-[[4-[[(2-Carboxyethyl)amino]-carbonyl]phenyl]azo-2-hydroxy-benzoic acid disodium salt
- CAS:
- 150399-21-6
- MF:
- C17H18N3NaO7
- MW:
- 399.33
- EINECS:
- 1533716-785-6
- Product Categories:
-
- COLAZAL
- Intermediates
- Mol File:
- 150399-21-6.mol
Balsalazide disodium Chemical Properties
- Melting point:
- >195°C (dec.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- Yellow
- Merck
- 14,945
- InChIKey
- XDCNKOBSQURQOZ-MVIJUDHYSA-L
- SMILES
- C(C1C(=CC=C(/N=N/C2C=CC(C(=O)NCCC(=O)O)=CC=2)C=1)O)(=O)O.[NaH].O
Balsalazide disodium Usage And Synthesis
Uses
antiinflammatory
Uses
Balsalazide Disodium Dihydrate is an analogue of Sulfasalazine (S699084), A prodrug of 5-aminosalicylic acid where carrier molecule is 4-aminobenzoyl-β-alanine. Anti-inflammatory (gastrointestinal).
Definition
ChEBI: The dihydrate of the disodium salt of balsalazide. A prodrug, releasing the anti-inflammatory 5-aminosalicylic acid (mesalazine) in the large intestine, it is used in the treatment of ulcerative colitis.
Indications
Balsalazide disodium is delivered intact to the colon, where it is cleaved by bacterial azoreduction to release equimolar quantities of mesalamine, the therapeutically active portion of the molecule, and 4-aminobenzoyl-β-alanine; the latter compound is only minimally absorbed and is largely inert.
brand name
Colazal (Salix).
in vivo
At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].
IC 50
IL-6; IL-1; STAT3
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