D-AP5 Chemical Properties

Melting point:

approximate 233℃

Boiling point:

482.1±55.0 °C(Predicted)

Density 

1.529±0.06 g/cm3(Predicted)

RTECS 

RD2513000

storage temp. 

Store at RT

solubility 

Soluble to 100 mM in sterile

form 

White solid

pka

2.46±0.10(Predicted)

color 

White

Water Solubility 

Soluble in water (100mM)

Sensitive 

Light Sensitive

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

D-AP5 Usage And Synthesis

Description

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (K_d = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.

Chemical Properties

white fine crystalline powder

Uses

A competitive NMDA antagonist

General Description

Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist.

Biological Activity

Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (L-(+)-2-Amino-5-phosphonopentanoic acid ). Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Product does not compete with ATP.

storage

Room temperature

D-AP5(79055-68-8)Related Product Information

• 12AP
• ANTI-IGM MU-CHAIN, RAT AP CONJ
• ANTI-IGG H AND L CHAIN, GOAT AP CONJ
• DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
• D-AP5
• 5-PHOSPHONOPENTANOIC ACID
• 4-AMINOBUTYLPHOSPHONIC ACID
• ANTI-IGG GAMMA-CHAIN, HUMAN AP CONJ
• ANTI-IGG, HUMAN AP CONJ
• ANTI-IMMUNOGLOBULIN A, HUMAN, AP
• ANTI-IGG, MOUSE AP CONJ
• 16-AP
• ANTI-IGG(H+L), HUMAN AP CONJ,ANTI-IGG H AND L CHAIN, HUMAN AP CONJ
• ANTI-IGG(H+L), RABBIT AP CONJ,ANTI-IGG H AND L CHAIN, RABBIT AP CONJ
• ANTI-IMMUNOGLOBULIN G, BOVINE, F(AB')2, AP
• ANTI-IGG H AND L CHAIN, HORSE AP CONJ
• ANTI-IMMUNOGLOBULIN G, CAT, F(AB')2, AP
• ANTI-IGM MU-CHAIN, HUMAN AP CONJ