DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID Chemical Properties

Melting point:

238-245oC

Boiling point:

482.1±55.0 °C(Predicted)

Density 

1.529±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

NH₄OH 1 M: 50 mg/mL, clear, colorless

form 

solid

pka

2.46±0.10(Predicted)

color 

white

Water Solubility 

Soluble to 10 mM in water and to 100 mM in 1eq. NaOH

BRN 

2446389

CAS DataBase Reference

76326-31-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

10

MSDS

• Language:English Provider:SigmaAldrich

DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID Usage And Synthesis

Uses

DL-2-Amino-5-phosphonopentanoic acid has been used:

• in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
• used in growth medium for inhibition of electrical activity in the neuronal network
• used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
• used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)

Definition

ChEBI: The 5-phosphono derivative of 2-aminopentanoic acid; acts as an N-methyl-D-aspartate receptor antagonist.

Biological Activity

Potent NMDA antagonist. See separate isomers (D-(-)-2-Amino-5-phosphonopentanoic acid and L-(+)-2-Amino-5-phosphonopentanoic acid ).

Biochem/physiol Actions

Anticonvulsant; potent and selective NMDA receptor antagonist.

storage

Room temperature

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