CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID CAS#: 110347-85-8

CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID Basic information

Product Name:

CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID

Synonyms:

4-(phosphonomethyl)-2-piperidinecarboxylic acid
CGS 19755
CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID
Selfotel
CGS-19755 \ POTENT COMPETITIVE NMDA RECE
cis-4-[Phosphomethyl]-piperidine-2-carboxylicacid
LY-272541
CPDD 0027

CAS:

110347-85-8

MF:

C7H14NO5P

MW:

223.16

Product Categories:

Glutamate receptor

Mol File:

110347-85-8.mol

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CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID Chemical Properties

Melting point:: 290-292 °C
Boiling point:: 508.6±60.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: H₂O: soluble
form: solid
pka: 2.29±0.10(Predicted)
color: white
Water Solubility: Soluble to 25 mM in water

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Safety Information

WGK Germany: 3

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CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACID Usage And Synthesis

Uses

CGS 19755 is a potent and competitive NMDA antagonist.

Definition

ChEBI: Selfotel is a non-proteinogenic alpha-amino acid.

Biological Activity

Potent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective. Also available as part of the Mixed NMDA Receptor Tocriset™ .

in vivo

Selfotel (CGS 19755) administered p.o. by gavage has little or no effect in these test procedures. In an experimental model of anxiety in rats^[1].
Selfotel (CGS 19755) significantly increases conflict responding within a relatively narrow dose range (minimum effective dose, 1.73 mg/kg i.p.)^[1].
Selfotel (CGS 19755) blocks the harmaline-induced increase in cerebellar cyclic GMP levels at a dose of 4 mg/kg i.p. with duration of action exceeding 2 hr^[2].
Selfotel (CGS 19755) inhibits convulsions elicited by maximal electroshock in rat (ED₅₀ = 3.8 mg/kg i.p. 1 hr after administration) and in mouse (ED₅₀ = 2.0 mg/kg i.p. 0.5 hr after administration)^[2].

storage

Store at RT

CIS-4-[PHOSPHONOMETHYL]-PIPERIDINE-2-CARBOXYLIC ACIDSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Email: info@chemlin.com.cn

EMMX Biotechnology LLC

Tel: 888-539-0666
Email: info@emmx.com

Amadis Chemical Company Limited

Tel: 571-89925085
Email: sales@amadischem.com

Wuxi AppTec

Tel: 022-59987777 13552403979
Email: jia_guoqiang@wuxiapptec.com

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