(R)-CPP Chemical Properties

Boiling point:

546.7±60.0 °C(Predicted)

Density 

1.408±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at RT

solubility 

Water: 100mM

form 

White crystalline powder.

pka

1.89±0.20(Predicted)

color 

White to off-white

Water Solubility 

Soluble to 100 mM in water

(R)-CPP Usage And Synthesis

Description

(R)-CPP is an NMDA receptor antagonist (K_i = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with K_i values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA₂ = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA₂ = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED₅₀ = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED₅₀ = 127 μmol/kg).

Uses

(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.

Biological Activity

Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).

storage

Room temperature (desiccate)

(R)-CPP(126453-07-4)Related Product Information

• 3-(N,N-Diethylamino)-L-alanine
• (R)-CPP
• (R)-2-(2,4-Dichlorophenoxy)propanoic acid
• 3-Aminopropylphosphonic acid
• D-2,3-Diaminopropionic acid
• 3-(N,N-Dimethylamino)-D-alanine
• D-SS-(N-METHYLAMINO)ALANINE
• PIPERAZINE-2-CARBOXYLIC ACID
• (R)-PIPERAZINE-2-CARBOXYLIC ACID
• 2-Piperazinemethanol
• 2-Piperazinecarboxaldehyde
• 4-METHYLPIPERAZINE-2-CARBOXYLIC ACID
• 4-CPP
• Aminoacylproline Carboxypeptidase, CPP, Penicillocarboxypeptidase S-1, Proline Carboxypeptidase,CPP【NMDA receptor antagonist】
• CHLORINATEDPOLYPROPYLENE(CPP)
• Apopain, CPP32, Yama
• azaleucine
• (+/-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID