L-701,252
L-701,252 Basic information
- Product Name:
- L-701,252
- Synonyms:
-
- L-701,252
- 7-CHLORO-3-(CYCLOPROPYL-CARBONYL)-4-HYDROXY-2(1H)-QUINOLINE
- 7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINONE
- 7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINE[L-701, 252]
- 7-Chloro-3-(cyclopropanecarbonyl)-4-hydroxyquinolin-2(1H)-one
- 7-chloro-3-[cyclopropyl(oxo)methyl]-2-hydroxy-1H-quinolin-4-one
- 2(1H)-Quinolinone, 7-chloro-3-(cyclopropylcarbonyl)-4-hydroxy-
- L-701252, 10 mM in DMSO
- CAS:
- 151057-13-5
- MF:
- C13H10ClNO3
- MW:
- 263.68
- Product Categories:
-
- Glutamate receptor
- Mol File:
- 151057-13-5.mol
L-701,252 Chemical Properties
- Boiling point:
- 516.8±50.0 °C(Predicted)
- Density
- 1.573±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- Soluble to 50 mM in DMSO
- form
- White crystalline solid.
- pka
- 4.50±1.00(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C13H10ClNO3/c14-7-3-4-8-9(5-7)15-13(18)10(12(8)17)11(16)6-1-2-6/h3-6H,1-2H2,(H2,15,17,18)
- InChIKey
- MXEFWCFPCLDOOG-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(Cl)=C2)C(O)=C(C(C2CC2)=O)C1=O
L-701,252 Usage And Synthesis
Uses
L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1].
Definition
ChEBI: 7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one is a quinolone and a hydroxyquinoline.
Biological Activity
An antagonist at the glycine-NMDA site (IC 50 = 420 nM). Also a potent systemic anticonvulsant.
in vivo
L-701252 (50 mg/kg; i.p.) provides a small non-significant protection[1].
| Animal Model: | 3-Months Male Mongolian gerbils (60 g)[1] |
| Dosage: | 50 mg/kg |
| Administration: | i.p. |
| Result: | Provided a small non-significant protection. |
IC 50
NMDA Receptor
storage
Desiccate at +4°C
References
[1] Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154. DOI:10.1016/s0165-6147(00)01451-6
[2] Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242. DOI:10.1016/s0006-8993(96)00779-2
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- L-701,252