2-Hexyl-1-decanol Chemical Properties

Melting point:

-21--15 °C (lit.)

Boiling point:

193-197 °C/33 mmHg (lit.)

Density 

0.836 g/mL at 25 °C (lit.)

vapor pressure 

0.4Pa at 148.85℃

refractive index 

n20/D 1.449(lit.)

Flash point:

113 °C

storage temp. 

Refrigerator

solubility 

Benzene (Sparingly), Chloroform (Sparingly), Methanol (Slightly)

pka

15.08±0.10(Predicted)

form 

Oil

color 

Clear Colourless

Cosmetics Ingredients Functions

SKIN CONDITIONING
SKIN CONDITIONING - EMOLLIENT

InChI

1S/C16H34O/c1-3-5-7-9-10-12-14-16(15-17)13-11-8-6-4-2/h16-17H,3-15H2,1-2H3

InChIKey

XULHFMYCBKQGEE-UHFFFAOYSA-N

SMILES

CCCCCCCCC(CO)CCCCCC

LogP

6.66 at 20℃

NIST Chemistry Reference

1-Decanol, 2-hexyl-(2425-77-6)

EPA Substance Registry System

1-Decanol, 2-hexyl- (2425-77-6)

Safety Information

WGK Germany 

nwg

TSCA 

TSCA listed

HS Code 

2905.19.9090

Storage Class

10 - Combustible liquids

2-Hexyl-1-decanol Usage And Synthesis

Uses

A compound isolated from different parts of Lonicera japonica Thunb. It is used in cosmetic and pharmaceutical preparations.

Uses

2-Hexyl-1-decanol may be employed as an organic solvent to study the extraction of non-polar acidic drugs from human plasma by parallel artificial liquid membrane extraction (PALME).

Definition

ChEBI: 2-hexyl-1-Decanol is an aliphatic alcohol.

General Description

2-Hexyl-1-decanol is a branched alcohol. It is one of the constituent of the essential oil, extracted from the roots of Adiantum flabellulatum. It is a long-chain glass forming monohydroxy alcohol and its dielectric relaxation at low temperature has been studied.

Synthesis

A method of preparing 2-hexyl-1-decanol (isomeric hexadecanol), the steps are as follows:

(1) 130g of n-octanol and 3.5g, 45wt% of aqueous sodium hydroxide solution were sequentially added to a 250ml three-necked flask and mixed, and then stirred at a speed of 250rpm for 8min and then warmed up to 165C, and reacted for 3h;

(2) the mixture of step (1) was cooled down to 20C afterward, and added 0.28 g zinc powder, stirring for 8min after heating to 195 , reaction 5h; and then continue to raise the temperature to 240 , reaction 30min, and then reduced to 20 ;

(3) the reaction product of step (2) to add 120g of n-heptane extraction, water washing to pH value of 6 ~ 7; control of the vacuum level is maintained at -0.096 ~ 0.098MPa, by decompression distillation, collection of 170 ~190 fraction, obtained 111.02 g colorless transparent liquid, that is, 2-hexyl-1-decanol (isomeric hexadecanol), yield 91.75%.

The WATER gel permeation chromatograph showed that the number average molecular weight of the colorless transparent liquid was 238 g/mol, Mw/Mn=1.05, and the hydroxyl content of the colorless transparent liquid was 7.15%, which was similar to the theoretical hydroxyl content of 7.02%, and it was determined that the product was isomeric hexadecanol (2-hexyl-1-decanol). The purity of the product was 96.79% by high performance liquid chromatography (HPLC).

2-Hexyl-1-decanol(2425-77-6)Related Product Information

• 1-Decanol
• HexanitrodiphenylaMine
• Isodecanol
• Ursodeoxycholic acid
• UVAOL
• G-STROPHANTHIN
• HECOGENIN ACETATE
• DIGITOXIGENIN
• 5-ALPHA-PREGNAN-3-ALPHA, 20-ALPHA-DIOL
• DIGOXIN
• Sodium cholate
• Digitoxin
• Betulinic acid
• CYMARIN
• Ursolic acid
• sodium (2-hexyldecyl) sulphate
• 1-Decanol, 2-hexyl-, dihydrogen phosphate
• 20ALPHA-HYDROXYCHOLESTEROL