- Product Name:
- GRATIBAIN 99%
- Product Categories:
- Mol File:
G-STROPHANTHIN Chemical Properties
- Melting point:
- Boiling point:
- 561.69°C (rough estimate)
- 1.1941 (rough estimate)
- refractive index
- -32 ° (C=1, H2O)
- storage temp.
- Desiccate at -20°C
- H2O: 10 mg/mL cold
- Water Solubility
- 13g/L(25 ºC)
- EPA Substance Registry System
- Ouabain (630-60-4)
- Language:English Provider:SigmaAldrich
G-STROPHANTHIN Usage And Synthesis
Ouabain is a white crystalline solid.
Odorless, white crystals or crystalline powder as an octahydrate. Used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998].
G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate)
Selective Na + , K + -ATPase inhibitor.
Poison by ingestion, intramuscular, intraperitoneal, intravenous, subcutaneous, and parented routes. Moderately toxic by intraduodenal route. A cardac stimulant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes
Ouabain, similar to digitoxin, is used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter; enzyme inhibitor.
UN1544 Alkaloids, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.).
- 010-82848833- ;010-82848833-
- K-strophanthin variable mixture
- STROPHANTHIN 3ALPHA-1-RHAMNOSIDE
- technetium Tc 99m K-strophanthin-beta
- STROPHANTHIN, g-(RG)
- K-STROPHANTHIN,STROPHANTHIN K,kombe-strophanthi
- K-STROPHANTHIN STANDARDIZED MIXTURE
- K-STROPHANTHIN-A,STROPHANTHIN K,K STROPHANTHIN,K-STROPHANTHIN-ALPHA
- 9-ANTHROYL OUABAIN
- BODIPY(R) FL OUABAIN
- Acocantherine, G-Strophanthin, 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside),G-STROPHANTHIN OCTAHYDRATE,STROPHANTHIN G,STROPHANTHIN G, OCTAHYDRATE
- OUABAIN [3H(G)]