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G-STROPHANTHIN

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G-STROPHANTHIN Basic information

Product Name:
G-STROPHANTHIN
Synonyms:
  • ouabageninl-rhamnoside
  • ouabaine
  • oubain
  • rectobaina
  • solufantina
  • strodival
  • strophalen
  • GRATIBAIN 99%
CAS:
630-60-4
MF:
C29H44O12
MW:
584.65
EINECS:
211-139-3
Product Categories:
  • Biochemistry
  • Glycosides
  • Rhamnose
  • Steroidglycosides
  • Steroids
  • Sugars
  • Inhibitors
Mol File:
630-60-4.mol
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G-STROPHANTHIN Chemical Properties

Melting point:
200°C
Boiling point:
561.69°C (rough estimate)
Density 
1.1941 (rough estimate)
refractive index 
-32 ° (C=1, H2O)
storage temp. 
Desiccate at -20°C
solubility 
H2O: 10 mg/mL cold
form 
powder
pka
13.04±0.70(Predicted)
color 
white
Water Solubility 
13g/L(25 ºC)
Merck 
6901
EPA Substance Registry System
Ouabain (630-60-4)
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Safety Information

Hazard Codes 
T
Risk Statements 
23/25-33
Safety Statements 
45
RIDADR 
UN 1544 6.1/PG 1
WGK Germany 
3
RTECS 
RN3850000
8
Toxicity
LD50 oral in guinea pig: 8280ug/kg

MSDS

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G-STROPHANTHIN Usage And Synthesis

Chemical Properties

Ouabain is a white crystalline solid.

General Description

Odorless, white crystals or crystalline powder as an octahydrate. Used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.

Reactivity Profile

When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998].

Health Hazard

G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.

Fire Hazard

When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate)

Biological Activity

Selective Na + , K + -ATPase inhibitor.

Safety Profile

Poison by ingestion, intramuscular, intraperitoneal, intravenous, subcutaneous, and parented routes. Moderately toxic by intraduodenal route. A cardac stimulant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes

Potential Exposure

Ouabain, similar to digitoxin, is used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter; enzyme inhibitor.

Shipping

UN1544 Alkaloids, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.).

G-STROPHANTHINSupplier

J & K SCIENTIFIC LTD.
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