HECOGENIN ACETATE Chemical Properties

Melting point:

246-248 °C (dec.)(lit.)

Boiling point:

95-140 °C

Density 

1.15±0.1 g/cm3(Predicted)

refractive index 

-4 ° (C=1, Dioxane)

storage temp. 

Refrigerator

solubility 

Chloroform (Sparingly), Dioxane (Sparingly, Heated), Ethyl Acetate (Slightly, Heated)

form 

Solid

color 

White

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

2937.29.9095

MSDS

• Language:English Provider:SigmaAldrich

HECOGENIN ACETATE Usage And Synthesis

Description

Hecogenin acetate is a steroid sapogenin and an acetylated form of hecogenin that has anthelmintic and antinociceptive properties. It reduces the percentage of mobile larvae in goat fecal cultures containing Haemonchus, Oesophagostomum, and Trichostrongylus nematodes (EC₅₀ = 0.49 mg/ml). Hecogenin acetate (5, 10, or 20 mg/kg, i.p.) inhibits development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine , and prostaglandin E₂ (PGE₂; ) in mice. It also increases latency to tail withdrawal in the tail flick test and has no effect on motor performance in the rotarod test in mice when administered at a dose of 40 mg/kg.

Uses

Hecogenin Acetate, is a derivative of Hecogenin (H129945), which is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties.

Definition

ChEBI: HECOGENIN ACETATE is a triterpenoid.

Purification Methods

Crystallise the acetate from MeOH. [Beilstein 19 IV 2583.]

HECOGENIN ACETATE(915-35-5)Related Product Information

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