Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Plant extracts >  Hecogenin

Hecogenin

Basic information Safety Supplier Related

Hecogenin Basic information

Product Name:
Hecogenin
Synonyms:
  • HECOGENIN
  • 5-ALPHA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL-12-ONE
  • 5ALPHA-SPIROSTAN-3BETA-OL-12-ONE
  • 3BETA-HYDROXY-5ALPHA-SPIROSTAN-12-ONE
  • 25R,5ALPHA-SPIROSTAN-3BETA-OL-12-ONE
  • Hecoginin
  • (25R)-5-Spirostan-3-ol-12-one
  • (3,5,25R)-3-Hydroxysiprostan-1
CAS:
467-55-0
MF:
C27H42O4
MW:
430.62
EINECS:
207-392-4
Product Categories:
  • 467-55-0
  • Biochemistry
  • Steroids (Others)
  • Steroids
Mol File:
467-55-0.mol
More
Less

Hecogenin Chemical Properties

Melting point:
268°C
alpha 
7.2 º (c=0.8 g/100ml, CHCl3)
Boiling point:
464.85°C (rough estimate)
Density 
1.0040 (rough estimate)
refractive index 
1.4840 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
15.10±0.70(Predicted)
form 
Solid
color 
White to Off-White
Merck 
14,4622
CAS DataBase Reference
467-55-0(CAS DataBase Reference)
More
Less

Safety Information

HS Code 
2937.29.9095

MSDS

More
Less

Hecogenin Usage And Synthesis

Uses

antiinflammatory

Uses

Hecogenin, is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties.

Definition

ChEBI: Hecogenin is a triterpenoid.

in vivo

Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1].

Animal Model:Male Swiss mice (20-30 g) with ethanol[1]
Dosage:3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg
Administration:Oral administration; for 15 hours
Result:Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.

Purification Methods

The saponin (~35 mg) in EtOAc is chromatographed on Al2O3 and eluted with *C6H6/Et2O, and the residue on evaporation is recrystallised from Me2CO. [Mazur et al. J Am Chem Soc 82 5889 1960, Marker et al. J Am Chem Soc 69 2167 1947, Beilstein 19 III/IV 2581.]

Hecogenin Preparation Products And Raw materials

Preparation Products

3beta-hydroxy-5alpha-pregna-9(11),16-dien-20-one 3-acetate 16,17-Epoxy-3-hydroxy-16-methyl-pregn-9(11)-ene-20-one-3-acetate16,17-Epoxy-16-methyl pregn-9(11)-en-3-ol-20-one3-Acetyloxy-16-methylpregna-9(11),16-dien-20-oneOxymetholone17-methyl-5alpha-androstane-3beta,17beta-diol (3,5,25R)-3-Hydroxyspirost-9(11)-ene16-beta Methyl Epoxide

HecogeninSupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Email
market03@meryer.com
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Email
Sales-CN@TCIchemicals.com
RYSS TECH LTD
Tel
400-188-0725 +86 21 34310725 13611771617
More
Less

Hecogenin(467-55-0)Related Product Information