ISOCYANOBENZENE Chemical Properties

Boiling point:

183.35°C (rough estimate)

Density 

1.0248 (rough estimate)

refractive index 

1.6760 (estimate)

solubility 

Chloroform (Soluble), Methanol (Slightly)

form 

Oil to Thick Oil

color 

Very Dark Red to Black

Safety Information

Risk Statements 

20/21/22

Safety Statements 

26-36/37/39

RIDADR 

UN 1672 6.1/ PGI

HazardClass 

6.1

PackingGroup 

I

ISOCYANOBENZENE Usage And Synthesis

Uses

Isocyanobenzene is used in the study of the inhibition mechanism of reconstituted cytochrome p-450scc-linked monooxygenase system by antimycotic reagent and other inhibitors.

Preparation

To a flask containing 7.9 gm (0.33 mole) of sodium hydride in 100 ml of tetrahydrofuran is slowly added a mixture of 9.3 gm (0.1 mole) of aniline and 25.3 gm (0.10 mole) of bromoform. After the addition, the reaction is stirred for 1-2 hr at room temperature, and water is added (100 ml) dropwise. Ether (200 ml) is added and the ether layer washed four times with 50-ml portions of water, three times with 20-ml portions of dilute hydrochloric acid, and then with water. The resulting ether layer is dried over sodium sulfate, concentrated, and the residue distilled to afford 4.7 gm (45%), b.p. 52-53°C (13 mm Hg).

Definition

ChEBI: Phenyl isocyanide is an isocyanide.

ISOCYANOBENZENE(931-54-4)Related Product Information

• Copper bis(2-ethylhexanoate)
• 2-BROMOPHENYL ISOCYANATE
• METHYL ISOCYANOACETATE
• Benzyl isocyanate
• 1,3,5-Tri-2-propenyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
• Ethyl Isocyanatoacetate
• 1,4-DIISOCYANOBENZENE
• 2,6-DIMETHYLPHENYL ISOCYANIDE
• 1-FLUORO-4-ISOCYANOBENZENE
• 1,1'-Methylenebis(4-isocyanobenzene)
• 1,2-DICHLORO-3-ISOCYANOBENZENE
• 1,3-DICHLORO-5-ISOCYANOBENZENE
• Benzene, 1-isocyano-3-nitro- (9CI)
• Benzonitrile, 3-isocyano- (9CI)
• Benzonitrile, 4-isocyano- (9CI)
• 1,2-DICHLORO-4-ISOCYANOBENZENE
• Benzene, 1-isocyano-4-nitro- (9CI)
• 1-(TRIFLUOROMETHYL)-3-ISOCYANOBENZENE