N-TRICOSANOYLTRYPTAMINE Chemical Properties

Melting point:

116-120 °C

Density 

1.54±0.1 g/cm3(Predicted)

storage temp. 

-20°C

form 

Solid

color 

White to off-white

biological source

rabbit

Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2

Safety Information

WGK Germany 

3

F 

10

MSDS

• Language:English Provider:SigmaAldrich

N-TRICOSANOYLTRYPTAMINE Usage And Synthesis

Uses

TAT-amide is a cell penetrating peptide. Cell-penetrating peptides (CPPs) are short amino acid sequences able to enter different cells[1][2].

Biological Activity

ATAT1 (α tubulin acetyltransferase 1) catalyses the acetylation of lysine 40 of α-tubulin and microtubule. ATAT1 expression is essential for microtubule stabilization and mediates cilium formation. Upart from acetylation, αTAT1 interacts with doublecortin (a microtubule associated protein) to degrade microtubules th at are not aligned with acetyltransferase activity. αTAT1 regulates the Wnt1 signalling pathway via β-catenin and promotes tumorigenesis. Overexpression of the ATAT1 gene is observed in colon cancer and is known to contribute to its progression.

References

[1] Xu P, et al. Precise control of apoptosis via gold nanostars for dose dependent photothermal therapy of melanoma. J Mater Chem B. 2019 Nov 28;7(44):6934-6944. DOI:10.1039/c9tb01956a
[2] Okuda-Shinagawa NM, et al. Fluorescent and Photosensitizing Conjugates of Cell-Penetrating Peptide TAT(47-57): Design, Microwave-Assisted Synthesis at 60 °C, and Properties. ACS Omega. 2017 Nov 30;2(11):8156-8166. DOI:10.1021/acsomega.7b01127

N-TRICOSANOYLTRYPTAMINE(697226-52-1)Related Product Information

• TYR-MET-GLU-HIS-PHE-ARG-TRP
• H-TYR-LYS-GLY-ARG-CYCLO(-GLU-TYR-ILE-LYS)-LEU-ILE-THR-ARG-PRO-ARG-TYR-NH2
• TYR-CORTICOTROPIN RELEASING FACTOR HUMAN, RAT
• TYR-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG
• TYR-ACTH (4-10)
• H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2
• TYR-LEPTIN (26-39) (HUMAN)
• TAT-Gap19
• TAT 2-4
• TAT-cyclo-CLLFVY
• TAT peptide
• L(+)-Arginine
• TRICOSANOIC ACID
• IL-18
• Human P
• GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-LYS-ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-LYS-ILE-LEU
• L-Arginine, L-α-aspartyl-L-seryl-L-leucyl-L-lysyl-L-seryl-L-tyrosyl-L-tryptophyl-L-tyrosyl-L-leucyl-L-glutaminyl-L-lysyl-L-phenylalanyl-L-seryl-L-tryptophyl-
• H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond)