3,5-DIIODO-4-PYRIDONE-1-ACETIC ACID Chemical Properties

Melting point:

244°C (dec.)

Boiling point:

422.8±45.0 °C(Predicted)

Density 

2.2000 (rough estimate)

refractive index 

1.7400 (estimate)

pka

3.60±0.10(Predicted)

Water Solubility 

2.787g/L(temperature not stated)

Sensitive 

Light Sensitive

CAS DataBase Reference

101-29-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

HazardClass 

IRRITANT

MSDS

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3,5-DIIODO-4-PYRIDONE-1-ACETIC ACID Usage And Synthesis

Originator

Iodopyracet,Winthrop

Uses

3,5-Diiodo-4-pyridone-1-acetic Acid is used in contrast media.

Definition

ChEBI: Diodone is a 4-pyridone in which the pyridone is iodo-substituted at C-3 and -5 and has a carboxymethyl substituent on nitrogen; used as a radiocontrast agent urography. It has a role as a radioopaque medium. It is a member of 4-pyridones, a monocarboxylic acid and an organoiodine compound.

Manufacturing Process

2 mol of pyridine are reacted with thionyl chloride to give 4-pyridyl-pyridinium chloride. The last one is transformed into 4-1H-pyridone by adding of water at 150°C. Then it is added to 1 mol of iodomonochloride (ICl) to give 3,5- diidopyridone. It is converted in 3.5-diiodo-4-pyridone-N-acetic acid by addition of chloroacetic acid and sodium hydrate. 1 mol of 3.5-diiodo-4- pyridone-N-acetic acid is dissolved in a solution of 1 mol of diethanolamine in 60 ml of water while heating. The solution is made up to 100 ml with water. After evaporating the solution and recrystallizing, the salt is obtained in the form of white crystals. MP: 153°C.

Therapeutic Function

Diagnostic aid

3,5-DIIODO-4-PYRIDONE-1-ACETIC ACID(101-29-1)Related Product Information

• 3-Pyridylacetic acid
• N,N-Dimethylglycine
• Propyliodone
• 3,5-DIIODO-4-PYRIDONE
• Iodoethane
• 4-HYDROXYPYRIDINE
• 1,3-Diiodopropane
• VINYL IODIDE
• 1-Iodopropane
• diodone
• 3,5-DIIODO-4-PYRIDONE-1-ACETIC ACID
• Ammonium iodide
• 1,3-DIIODOACETONE
• (4-OXO-4H-PYRIDIN-1-YL)ACETIC ACID
• DIHYDROPYRIDINE
• 3-IODO-1H-PYRIDIN-4-ONE
• 1,4-DIHYDRO-3,5-DIIODO-4-OXO-1-PYRIDINEACETIC ACID DIETHYLAMINE SALT
• 2-IODOPROPENE