6-METHYLOXINDOLE Chemical Properties

Melting point:

179-180 °C(Solv: water (7732-18-5); ethanol (64-17-5))

Boiling point:

315.0±41.0 °C(Predicted)

Density 

1.155±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

14.31±0.20(Predicted)

Appearance

Orange to red Solid

Safety Information

HS Code 

2933998090

6-METHYLOXINDOLE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 6-methylindolone from 3-methylacetanilide and ethyl iodoacetate was as follows: first, 3-methylacetanilide (0.5 mmol), Pd(OAc)2 (11.3 mg, 0.05 mmol, 10 mol%), and AgOAc (83.5 mg, 0.5 mmol) were added to a 15 mL sealed tube fitted with a septum. Subsequently, the system was evacuated and purged three times with nitrogen. TFA (4.0 mL) and ethyl 2-iodoacetate (160 mg, 0.75 mmol) were added to the system, and the reaction mixture was stirred at 120 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered through a short diatomaceous earth pad and washed several times with CH2Cl2. The filtrate was concentrated under vacuum and purified by silica gel column chromatography using hexane/EtOAc as eluent to give the final pure 6-methylindolone product.

References

[1] Synthesis (Germany), 2016, vol. 48, # 12, p. 1872 - 1879

6-METHYLOXINDOLE(56341-38-9)Related Product Information

• 6-METHYL-2,3-DIHYDRO-1H-INDOLE
• Methyl 2-oxoindole-6-carboxylate
• 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID
• 6-methyl-1H-indole-2,3-dione
• 6-TRIFLUOROMETHYLOXINDOLE
• 6-CYANOOXINDOLE
• 6-Methylindole
• Oxindole
• 3-HYDROXY-2-OXO-3-TRIFLUOROMETHYL-6-METHYLINDOLINE
• 6,78,9 TETRAHYDROBEZ(G) ISATIN
• 6-ETHYL ISATIN
• (+/-)-BMS 204352
• 6-(4-METHOXY-PHENYL)-1,3-DIHYDRO-INDOL-2-ONE
• 6,7-dimethylisatin
• 5,6-Dimethylisatin
• 4,6-DIMETHYL-1H-INDOLE-2,3-DIONE
• 3-[(Z)-(5-CHLORO-2-HYDROXYPHENYL)METHYLIDENE]-6-(TRIFLUOROMETHYL)-1H-INDOL-2-ONE
• N-(4-([2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3H-INDOL-3-YLIDEN]METHYL)PHENYL)ACETAMIDE