RU 26752
RU 26752 Basic information
- Product Name:
- RU 26752
- Synonyms:
-
- 7-propyl spirolactone
- 17α-Hydroxy-3-oxo-7α-propylpregn-4-ene-21-carboxylic acid γ-lactone
- (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylicacidγ-lactone
- Pregn-4-ene-21-carboxylic acid, 17-hydroxy-3-oxo-7-propyl-, γ-lactone, (7α,17α)-
- CAS:
- 76676-33-0
- MF:
- C25H36O3
- MW:
- 384.56
- Mol File:
- 76676-33-0.mol
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RU 26752 Chemical Properties
- Boiling point:
- 546.7±50.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 20 mg/mL at 60 °C warming up for 20 minutes, soluble
- form
- solid
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RU 26752 Usage And Synthesis
Uses
RU 26752 is a steroid hormone receptor antagonist. RU 26752 can prevent hypertension caused by aldosterone (HY-113313) in rats[1].
Biological Activity
Mineralocorticoid receptor antagonist. Prevents aldosterone-induced hypertension in rats.
References
[1] M Kalimi, et al. Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats. Am J Physiol. 1990 May;258(5 Pt 1):E737-9. DOI:10.1152/ajpendo.1990.258.5.E737