ADENOSINE AMINE CONGENER (ADAC)
ADENOSINE AMINE CONGENER (ADAC) Basic information
- Product Name:
- ADENOSINE AMINE CONGENER (ADAC)
- Synonyms:
-
- N6-[4-[[[4-[[[(2-AMinoethyl)aMino]carbonyl]Methyl]-anilino]carbonyl]Methyl]phenyl]adenosine hydrate
- ADENOSINE AMINE CONGENER (ADAC)
- ADAC, N6-[4-[[[4-[[[(2-Aminoethyl)amino]carbonyl]methyl]-anilino]carbonyl]methyl]phenyl]adenosine hydrate
- Adenosine amine congener hydrate
- N-[4-[2-[[4-[2-[(2-Aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]adenosine
- Adenosine, N-[4-[2-[[4-[2-[(2-aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]-
- N-(2-Aminoethyl)-2-(4-(2-(4-((9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)phenyl)acetamido)phenyl)acetamide
- P1 receptor,otoprotective,Adenosine amine congener,Adenosine Receptor,loss,hearing,Inhibitor,apoptotic,injury,systemic,A1-adenosine,Cochlear,inhibit,Ca2+,neuroprotective
- CAS:
- 96760-69-9
- MF:
- C28H32N8O6
- MW:
- 576.6
- Product Categories:
-
- API
- Mol File:
- 96760-69-9.mol
ADENOSINE AMINE CONGENER (ADAC) Chemical Properties
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- 0.1 M acetic acid: 12 mM
- pka
- 13.11±0.70(Predicted)
- form
- solid
- color
- white
Safety Information
- Safety Statements
- 22-24/25
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
ADENOSINE AMINE CONGENER (ADAC) Usage And Synthesis
Uses
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects[1][2].
in vivo
Adenosine amine congener (25-300?μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50?μg/kg, providing up to 21?dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner[1].
| Animal Model: | Male Wistar rats (8-10 weeks old) treated with noise exposure[1] |
| Dosage: | 25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300?μg/kg/day |
| Administration: | Intraperitoneal injection; daily; for 5 days |
| Result: | Most effective in the first 24 hours after noise exposure at doses >50?μg/kg, and provided up to 21?dB protection (averaged across 8-28?kHz). |
References
[1] Vlajkovic SM, et al. Adenosine amine congener as a cochlear rescue agent. Biomed Res Int. 2014;2014:841489. DOI:10.1155/2014/841489
[2] Vlajkovic SM, et al. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signal. 2010 Jun;6(2):273-81. DOI:10.1007/s11302-010-9188-5
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